SMILE来源的角膜基质透镜临床再利用的研究进展  

Research progress in clinical reuse of small incision lenticule extraction-derived lenticule

作　　者：黄青 张奕霞 蹇骞 Huang Qing;Zhang Yixia;Jian Qian(Department of Refractive Surgery,Chongqing Nanping Aier Eye Hospital,Chongqing 400060,China)

机构地区：[1]重庆南坪爱尔眼科医院屈光手术科,中国重庆市400060

出　　处：《国际眼科杂志》2024年第11期1759-1763,共5页International Eye Science

基　　金：2021年南岸区科卫联合医学科研项目(No.2021-25);2021年爱尔眼科医院集团科研基金项目(No.AF2116D6)。

摘　　要：随着飞秒激光小切口角膜基质透镜取出术(SMILE)的普及,术中大量一片式角膜基质透镜被取出。角膜基质透镜作为手术的额外产物,对其进行基础研究及临床再利用已成为近年来的研究热点。角膜基质透镜薄而透明,来源丰富,成本低廉,具有低免疫源性及良好的组织相容性等优点,是研究细胞和角膜基质的重要来源,也可作为临床上角膜加固、补片移植、屈光矫正及泪道栓塞的良好生物材料。文章就SMILE手术来源的角膜基质透镜在治疗角膜相关疾病,矫治远视及老视,覆盖青光眼引流阀防止其暴露及用于泪道栓等方面的应用进行综述,旨在充分认识其在临床上的再利用,扩大其手术应用范围,为其他眼病的治疗及组织器官中的应用提供新方向。With the popularization of small incision lenticule extraction(SMILE),a large number of one-piece corneal stromal lenticules are removed during surgery.As an additional product of surgery,the experimental research and clinical reuse of extracted corneal stromal lenticules from SMILE have become a research hotspot in recent years.Corneal stromal lenticules are thin and transparent,rich in sources,low in cost,and have the advantages of low immunogenicity and good tissue compatibility,so they can be used as important source of cells and corneal stroma research,and also can be used as good biomaterials for corneal reinforcement,patch graft,refractive correction,and lacrimal duct embolization in clinical study.This article reviews the clinical application of SMILE-derived lenticule in the treatment of corneal-related diseases,correction of hyperopia and presbyopia,coverage of glaucoma drainage valve to prevent their exposure,and its use in lacrimal duct plug,aiming to fully recognize the reuse of lenticules in clinical practice,expand its surgical indication,and providing new directions for the treatment of other eye diseases and its application in tissues and organs.

关 键 词：飞秒激光小切口角膜基质透镜取出术(SMILE) 角膜基质透镜 再利用 角膜溃疡穿孔 远视 老视 

分 类 号：R779.63[医药卫生—眼科]