银川市体检人群代谢相关脂肪性肝病现状调查及影响因素分析  

Investigation on the Current Status and Influencing Factors of Metabolic Related Fatty Liver Disease among the Population Undergoing Physical Examination in Yinchuan City

作　　者：方昱 杨少奇[2] 王芳[2] 张丽娜[2] 苏晓乾[3] FANG Yu;YANG Shaoqi;WANG Fang;ZHANG Lina;SU Xiaoqian(Ningxia Medical University,Yinchuan 750004,China;The First Clinical Medical College of Ningxia Medical University,Department of Gastroenterology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Health Management Center,General Hospital of Ningxia Medical University,The First Clinical Medical College of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院消化内科,宁夏医科大学第一临床医学院,银川750004 [3]宁夏医科大学总医院健康管理中心,宁夏医科大学第一临床医学院,银川750004

出　　处：《宁夏医科大学学报》2024年第8期830-835,共6页Journal of Ningxia Medical University

基　　金：国家重点专项课题项目(2018YFC1311504)。

摘　　要：目的分析银川市体检人群代谢相关脂肪性肝病(MAFLD)现状、临床特征及危险因素,为深入开展防控工作提供参考依据。方法以2020年1月1日至12月31日在宁夏医科大学总医院健康体检的银川市常住居民为研究对象,分析其一般资料、实验室指标等检测结果。结果共纳入体检人员12865人,MAFLD患者4155例,患病率32.30%;男性患者3122例,患病率41.60%;女性患者1033例,患病率19.27%;男性患病率高于女性(χ^(2)=436.104,P<0.01)。>60岁人群中,女性患病率(40.97%)高于男性(31.47%)(P<0.01)。MAFLD组的三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、丙氨酸转氨酶、尿酸水平与非MAFLD组比较,差异均有统计学意义(P均<0.05)。多因素Logistic回归分析显示,男性、天冬氨酸转移酶及肌酐是MAFLD的独立危险因素(P均<0.05)。结论银川市体检人群MAFLD患病率较高,且男性和肥胖者居多。男性、天冬氨酸转移酶、肌酐是MAFLD的影响因素。Objective To investigate the current situation of metabolic associated fatty liver disease(MAFLD)in the physical examination population in Yinchuan,analyze its clinical characteristics and risk factors,and provide a reference basis for in-depth intervention,prevention,and control work.Methods The health checkups of permanent residents of Yinchuan City at the General Hospital of Ningxia Medical University from January 2020 to December were used as the study population,and the test results of general conditions and laboratory indicators were collected and statistically analyzed.Results A total of 12865 physical examinations personnel were included,and 4155 patients with MAFLD(32.30%),including 3122 males(41.60%)and 1033 females(19.27%),the prevalence of males was higher than that of females(X^(2)=436.104,P<0.01).The prevalence rate of women(40.97%)was higher than that of men(31.47%),and the difference was statistically significan(t P<0.01).The differences in triglycerides,total cholesterol,low-density lipoprotein,high-density lipoprotein,alanine aminotransferase,and uric acid in the MAFLD group were significant compared to the non-MAFLD group(P all<0.05).Multifactorial Logistic regression analysis showed that males,aspartate aminotransferase,and creatinine were independent risk factors for MAFLD,and the differences were statistically significan(t P all<0.05).Conclusion The prevalence of MAFLD is high in the Yinchuan city physical examination population,with a predominance of males and obese individuals,and males,aspartate aminotransferase,and creatinine are the influencing factors of MAFLD.

关 键 词：代谢相关脂肪性肝病 患病率 影响因素 

分 类 号：R575.5[医药卫生—消化系统]