ABC转运蛋白调控牙龈卟啉单胞菌致病力的研究进展  

Research progress on roles of ATP⁃binding cassette transporters in Porphyromonas gingivalis pathogenicity

作　　者：吴诗文 赵川江[1] 高雳 WU Shiwen;ZHAO Chuanjiang;GAO Li(Department of Periodontology,Hospital of Stomatology,Sun Yat-Sen University,Guangdong Provincial Key Laboratory of Stomatology,Guanghua School of Stomatology,Sun Yat-Sen University,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院牙周病科,广东省口腔医学重点实验室,中山大学光华口腔医学院,广东广州510055

出　　处：《口腔生物医学》2024年第5期287-290,296,共5页Oral Biomedicine

基　　金：国家自然科学基金(82170959);广东省自然科学基金(2022A1515010855)。

摘　　要：腺苷三磷酸结合盒转运蛋白(ABC转运蛋白)是在所有物种中均存在的庞大且高度保守的转运蛋白基因家族,可调控多种微生物的致病力,在微生物适应宿主环境和在对抗抗生素中发挥重要作用。牙龈卟啉单胞菌(P.gingivalis)是牙周炎的重要致病菌,其致病力受到多种毒力因子调控。本文就ABC转运蛋白的结构和功能及其调控P.gingivalis致病力的研究进展作一综述。The adenosine triphosphate binding cassette transporter(ABC transporters),as one of the largest transmembrane protein superfamilies,are found in all domains of life and highly conservative.Bacterial ABC transporters are essential for the pathogenicity of a wide range of microorganisms,and play a vital role in their adaptation to the environment and antibiotic resistance.Porphyromonas gin⁃givalis(P.gingivalis)is a major pathogen of periodontitis,and its pathogenicity is regulated by several virulence factors.In this arti⁃cle,we review the structure and function of ABC transporters,and their regulation to the P.gingivalis pathogenicity.

关 键 词：ABC转运蛋白 牙龈卟啉单胞菌 致病力 

分 类 号：R780.2[医药卫生—口腔医学]