Dnmt3b与颞下颌关节骨关节炎关系的研究进展  

Research advances of Dnmt3b on temporomandibular joint osteoarthritis

作　　者：杨慧 苏俭生[1] 周玥 YANG Hui;SU Jiansheng;ZHOU Yue(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Prosthodontics,Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China;Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Endodontics,Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属口腔医院口腔修复科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072 [2]同济大学附属口腔医院牙体牙髓科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072

出　　处：《口腔生物医学》2024年第5期303-306,共4页Oral Biomedicine

基　　金：国家自然科学基金青年科学基金项目(82001069);上海市卫生健康委员会卫生行业临床研究专项青年基金项目(20194Y0438)。

摘　　要：颞下颌关节骨关节炎(TMJOA)是一种以进行性软骨退化、软骨下骨改建、颞下颌关节(TMJ)慢性疼痛为特征的常见疾病,发病机制尚不明确。DNA甲基转移酶3b(Dnmt3b)是一种DNA甲基转移酶,能促进TMJ的修复再生。本文就Dnmt3b在TMJOA方面的研究进展进行综述,以期为治疗TMJOA提供新思路。Temporomandibular joint osteoarthritis(TMJOA)is a common disease characterized by progressive cartilage degenera⁃tion,subchondral bone remodeling and chronic pain.The exact pathogenesis of TMJOA is unclear.Dnmt3b is a kind of DNA methyl⁃transferase,which can promote the repair and regeneration of temporomandibular joint.This review summarizes the research progress of Dnmt3b in TMJOA,in order to provide a new idea for the treatment of TMJOA.

关 键 词：DNA甲基转移酶3B 颞下颌关节骨关节炎 表观遗传学 

分 类 号：R782.6[医药卫生—口腔医学]