Do wearing masks and preservatives have a combined effect on skin health?  

作　　者：Yu Liu Leijian Chen Shuyi Zhang Xiaoxiao Wang Yuanyuan Song Hongwen Sun Zongwei Cai Lei Wang 

机构地区：[1]MOE Key Laboratory of Pollution Processes and Environmental Criteria,College of Environmental Science and Engineering,Nankai University,Tianjin 300350,China [2]State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong 999077,China

出　　处：《Eco-Environment & Health》2024年第1期107-115,共9页生态环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(U22A20614&41722304);the Ministry of Education,China(T2017002).

摘　　要：Chemical exposure and local hypoxia caused by mask-wearing may result in skin physiology changes.The effects of methylparaben(MeP),a commonly used preservative in personal care products,and hypoxia on skin health were investigated by HaCaT cell and ICR mouse experiments.MeP exposure resulted in lipid peroxidation and interfered with cellular glutathione metabolism,while hypoxia treatment disturbed phenylalanine,tyrosine,and tryptophan biosynthesis pathways and energy metabolism to respond to oxidative stress.A hypoxic environment increased the perturbation of MeP on the purine metabolism in HaCaT cells,resulting in increased expression of proinflammatory cytokines.The synergistic effects were further validated in a mouse model with MeP dermal exposure and“mask-wearing”treatment.CAT,PPARG,and MMP2 were identified as possible key gene targets associated with skin health risks posed by MeP and hypoxia.Network toxicity analysis suggested a synergistic effect,indicating the risk of skin inflammation and skin barrier aging.

关 键 词：MEP HYPOXIA Synergistic effect Skin metabolomics Network toxicology 

分 类 号：R1[医药卫生—公共卫生与预防医学]