Dihalogenated nitrophenols in drinking water:Prevalence,resistance to household treatment,and cardiotoxic impact on zebrafish embryo  

作　　者：Hongjie Sun Yingying Liu Chunxiu Wu Lena QMa Dongxing Guan Huachang Hong Haiying Yu Hongjun Lin Xianfeng Huang Peng Gao 

机构地区：[1]Key Laboratory of Watershed Earth Surface Processes and Ecological Security,College of Geography and Environmental Science,Zhejiang Normal University,Jinhua 321004,China [2]College of Chemistry and Life Science,Zhejiang Normal University,Jinhua 321004,China [3]Institute of Soil and Water Resources and Environmental Science,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China [4]National and Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution,College of Life and Environmental Science,Wenzhou University,Wenzhou 325035,China [5]Department of Environmental and Occupational Health,and Department of Civil and Environmental Engineering,University of Pittsburgh,Pittsburgh,PA 15261,United States [6]UPMC Hillman Cancer Center,Pittsburgh,PA 15232,United States

出　　处：《Eco-Environment & Health》2024年第2期183-191,共9页生态环境与健康（英文）

基　　金：supported by Jinhua Public Welfare Technology Application Research Project(2022-4-046);the Open Fund Project of Key Laboratory of Watershed Earth Surface Processes and Ecological Security of Zhejiang Normal University(KF-2022-15);the Foundation Natural Science Foundation of Zhejiang Province(LQ21D010008);the University of Pittsburgh Momentum Funds 2022-23(006068);the University of Pittsburgh Competitive Medical Research Fund 2023-24(006559).

摘　　要：Dihalogenated nitrophenols(2,6-DHNPs),an emerging group of aromatic disinfection byproducts(DBPs)detected in drinking water,have limited available information regarding their persistence and toxicological risks.The present study found that 2,6-DHNPs are resistant to major drinking water treatment processes(sedimentation and filtration)and households methods(boiling,filtration,microwave irradiation,and ultrasonic cleaning).To further assess their health risks,we conducted a series of toxicology studies using zebrafish embryos as the model organism.Our findings reveal that these emerging 2,6-DHNPs showed lethal toxicity 248 times greater than that of the regulated DBP,dichloroacetic acid.Specifically,at sublethal concentrations,exposure to 2,6-DHNPs generated reactive oxygen species(ROS),caused apoptosis,inhibited cardiac looping,and induced cardiac failure in zebrafish.Remarkably,the use of a ROS scavenger,N-acetyl-l-cysteine,considerably mitigated these adverse effects,emphasizing the essential role of ROS in 2,6-DHNP-induced cardiotoxicity.Our findings highlight the cardiotoxic potential of 2,6-DHNPs in drinking water even at low concentrations of 19μg/L and the beneficial effect of N-acetyl-l-cysteine in alleviating the 2,6-DHNP-induced cardiotoxicity.This study underscores the urgent need for increased scrutiny of these emerging compounds in public health discussions.

关 键 词：Dihalogenated nitrophenols Household water treatment Zebrafish embryo Reactive oxygen species CARDIOTOXICITY 

分 类 号：X52[环境科学与工程—环境工程]