CD64指数、系统免疫炎症指数、CRP/Alb比值与肝癌肝部分切除术患者术后感染的关系  

Relationship between CD64 Index,Systemic Immune Inflammation Index,CRP/Alb Ratio and Postoperative Infection in Patients with Partial Hepatectomy for Liver Cancer

作　　者：翟鸿烨 王伟 张利军 袁晖 白重阳 柳琳 桂玉婷 翟达 ZHAI Hong-ye;WANG Wei;ZHANG Li-jun;YUAN Hui;BAI Chong-yang;LIU Lin;GUI Yu-ting;ZHAI Da(Department of Clinical Laboratory,The Second Affiliated Hospital of Air Force Military Medical University,Xian,Shaanxi,710038,China;Department of Infectious Diseases,The Second Affiliated Hospital of Air Force Military Medical University,Xian,Shaanxi,710038,China;Department of Laboratory,The Second Affiliated Hospital of Air Force Military Medical University,Xian,Shaanxi,710038,China)

机构地区：[1]空军军医大学第二附属医院检验科,陕西西安710038 [2]空军军医大学第二附属医院感染病科,陕西西安710038 [3]空军军医大学第二附属医院实验室,陕西西安710038

出　　处：《现代生物医学进展》2024年第17期3342-3347,共6页Progress in Modern Biomedicine

基　　金：陕西省自然科学基础研究计划项目(2022JQ-921)。

摘　　要：目的:探讨分化簇64(CD64)指数、系统免疫炎症指数(SII)、C反应蛋白/白蛋白(CRP/Alb)比值与肝癌肝部分切除术(PR)患者术后感染的关系。方法:选取2021年1月~2023年10月在我院行PR的肝癌患者300例,根据是否发生术后感染分为感染组和无感染组,计算CD64指数、SII、CRP/Alb比值。采用多因素Logistic回归分析肝癌PR患者术后感染的因素,受试者工作特征(ROC)曲线分析CD64指数、SII、CRP/Alb比值对肝癌PR患者术后感染的预测价值。结果:300例肝癌PR患者术后感染发生率为21.33%(64/300)。与无感染组比较,感染组CD64指数、SII、CRP/Alb比值升高(P<0.05)。多因素Logistic回归分析显示糖尿病、术中输血、引流管放置时间≥7 d和CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素(P<0.05)。CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的曲线下面积为0.910,大于CD64指数、SII、CRP/Alb比值单独预测的0.790、0.778、0.776。结论:CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素,CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的价值较高。Objective:To investigate the relationship between cluster of differentiation 64(CD64)index,systemic immune inflammation index(SII),C-reactive protein/albumin(CRP/Alb)ratio and postoperative infection in patients with partial hepatectomy(PR)for liver cancer.Methods:300 patients with liver cancer who underwent PR in our hospital from January 2021 to October 2023 were selected and divided into infection group and non-infection group according to whether postoperative infection occurred,the CD64 index,SII and CRP/Alb ratio were calculated.The factors of postoperative infection in patients with liver cancer PR were analyzed by multivariate Logistic regression analysis,the predictive value of CD64 index,SII and CRP/Alb ratio for postoperative infection in patients with liver cancer PR were analyzed by receiver operating characteristic(ROC)curve.Results:The incidence of postoperative infection in 300 patients with liver cancer PR was 21.33%(64/300).Compared with non-infected group,the CD64 index,SII and CRP/Alb ratio in infected group increased(P<0.05).Multivariate Logistic regression analysis showed that diabetes mellitus,intraoperative blood transfusion,drainage tube placement time≥7 d and elevated CD64 index,SII,CRP/Alb ratio were independent risk factors for postoperative infection in patients with liver cancer PR(P<0.05).The area under the curve of CD64 index,SII and CRP/Alb ratio in predicting postoperative infection of PR patients with liver cancer was 0.910,which was greater than 0.790,0.778 and 0.776 predicted by CD64 index,SII and CRP/Alb ratio alone(P<0.05).Conclusion:The increase of CD64 index,SII and CRP/Alb ratio are independent risk factor for postoperative infection in PR patients with liver cancer,the combination of CD64 index,SII and CRP/Alb ratio has higher value in predicting postoperative infection in PR patients with liver cancer.

关 键 词：肝癌 肝部分切除术 分化簇64指数 系统免疫炎症指数 C反应蛋白/白蛋白比值 感染 

分 类 号：R735.7[医药卫生—肿瘤]