多发性骨髓瘤患者血清细胞因子和T细胞免疫功能水平与Mayo分层及预后的相关性  

The correlation between serum cytokine and T cell immune function levels and Mayo stratification in patients with multiple myeloma

作　　者：李书芹 杨志勇 吴忆帆 陆静忠 LI Shuqin;YANG Zhiyong;WU Yifan;LU Jingzhong(Hematology Department,Chongming Hospital Affiliated to Shanghai Health Medical College,Shanghai 202150,China;Oncology Department,Chongming Hospital Affiliated to Shanghai Health Medical College,Shanghai 202150,China)

机构地区：[1]上海健康医学院附属崇明医院血液科,上海202150 [2]上海健康医学院附属崇明医院肿瘤科,上海202150

出　　处：《中南医学科学杂志》2024年第5期808-810,842,共4页Medical Science Journal of Central South China

基　　金：上海市崇明区科学技术委员会可持续发展科技创新行动计划(CKY2020-37)。

摘　　要：目的 探讨多发性骨髓瘤患者血清细胞因子和T细胞免疫功能水平与Mayo分层及预后的相关性。方法 80例多发性骨髓瘤患者按Mayo分层分为高危组(18例)、中危组(38例)、标危组(24例)。比较各组患者血清细胞因子白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF),以及T细胞免疫功能指标CD3^(+)、CD4^(+)、CD8^(+)、NK细胞水平。采用Pearson相关性分析探讨各指标与Mayo分层及预后的相关性。结果 不同Mayo分层患者血清IL-6、IL-8、TNF-α、VEGF、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异均有显著性(P<0.05);多发性骨髓瘤患者血清细胞因子IL-6、IL-8、TNF-α、VEGF与Mayo分层均呈正相关(P<0.05);多发性骨髓瘤患者细胞免疫功能水平CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)与预后均呈负相关(P<0.05)。结论 动态监测血清相关细胞因子及免疫功能有助于评价病情及预后。Aim To investigate the correlation between serum cytokine and T cell immune function levels and Mayo stratification and prognosis in patients with multiple myeloma.Methods 80 patients with multiple myeloma were divided into high-risk group(18 cases),medium risk group(38 cases),and standard risk group(24 cases) according to Mayo stratification.The levels of serum interleukin-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α),vascular endothelial growth factor(VEGF),CD3~+,CD4~+,CD8~+,and NK cells in each group of patients were compared.Pearson correlation analysis was used to explore the correlation between IL-6,IL-8,TNF-α,VEGF,NLR,CD3~+,CD4~+,CD8~+,NK,CD4~+/CD8~+levels and Mayo stratification and prognosis.Results The results showed that there were significant differences(P<0.05) in the levels of serum IL-6,IL-8,TNF-α,VEGF,CD3~+,CD4~+,CD8~+,and CD4~+/CD8~+among patients with different Mayo stratification;IL-6,IL-8,TNF-α,and VEGF in patients with multiple myeloma were positively correlated with Mayo stratification(P<0.05);The serum cytokines of CD3~+,CD4~+,CD8~+,CD4~+/CD8~+in patients with multiple myeloma were negatively correlated with prognosis(P<0.05).Conclusion Mayo stratification can predict prognosis,and dynamic monitoring of serum related cytokines and immune function can help evaluation of the condition and prognosis.

关 键 词：多发性骨髓瘤 细胞因子 T细胞免疫功能 Mayo分层 预后 

分 类 号：R739.42[医药卫生—肿瘤]