粪便移植对肠易激综合征患者肠道菌群及脑肠菌轴、IFN-γ、IL-4水平的调节作用  

Regulatory effects of fecal microbiota transplantation on gut microbiota,brain-enteric-bacteria axis,IFN-γ and IL-4 levels in patients with irritable bowel syndrome

作　　者：田金媚 赵彩红[1] TIAN Jinmei;ZHAO Caihong(Department of Gastroenterology,Harrison International Peace Hospital,Hengshui 053000,Hebei,China)

机构地区：[1]哈励逊国际和平医院消化内科,河北衡水053000

出　　处：《中南医学科学杂志》2024年第5期823-826,共4页Medical Science Journal of Central South China

基　　金：衡水市科技计划项目(20210140827)。

摘　　要：目的 探究粪便移植对肠易激综合征(IBS)患者肠道菌群及脑肠菌轴、γ干扰素(IFN-γ)、白细胞介素(IL)-4水平的调节作用。方法 选取138例IBS患者,根据治疗方法分为粪便移植组(62例)和益生菌组(76例)。比较两组治疗前后肠道菌群、IFN-γ、IL-4、胃肠功能(血管活性肠肽、生长抑素、P物质、胃动素水平)、IBS生活质量量表(IBS-QOL)评分、IBS严重程度评分系统(IBS-SSS)、胃肠道症状评定量表(GSRS)评分及临床疗效。结果 治疗后,两组肠杆菌、肠球菌及酵母菌数量、IFN-γ、IL-4、IBS-QOL、IBS-SSS、GSRS评分、血管活性肠肽、生长抑素下降,乳酸杆菌、双歧杆菌数量、IL-4、P物质、胃动素升高;且粪便移植组改善较益生菌组更为显著(P<0.05)。粪便移植组治疗总有效率高于益生菌组(P<0.05)。结论 粪便移植可帮助IBS患者重建肠道微生态平衡,提高临床疗效及生活质量,促进胃肠功能恢复。Aim To explore the regulatory effect of fecal microbiota transplantation on gut microbiota,brain-enteric-bacteria axis,interferon-γ(IFN-γ) and interleukin-4(IL-4) levels in patients suffered from irritable bowel syndrome.Methods 138 patients with IBS were selected and divided into fecal transplantation group(62 cases) and probiotic group(76 cases),according to the treatment methods.Intestinal flora,IFN-γ,IL-4,gastrointestinal function(vasoactive intestinal peptide,somatostatin,substance P,motilin levels),as well as IBS quality of life scale(IBS-QOL),IBS severity system score(IBS-SSS),gastrointestinal symptom rating scale(GSRS) before and after treatment,and clinical efficacy of the two groups were compared.Results After treatment,the number of enterobacterium,enterococcus and yeast,IFN-γ,IL-4,IBS-QOL,IBS-SSS,GSRS scores,vasoactive intestinal peptides and somatostatin decreased in both groups,while the number of lactobacillus,bifidobacterium,IL-4,substance P and motilin increased.The improvement of fecal transplantation group was more significant than that of probiotic group(P<0.05).The total effective rate of fecal transplantation group was higher than that of probiotic group(P<0.05).Conclusion Fecal transplantation can help IBS patients rebuild intestinal microecological balance,improve clinical efficacy and quality of life,and promote the recovery of gastrointestinal function.

关 键 词：粪便移植 IBS IFN-Γ IL-4 胃肠功能 脑肠菌轴 

分 类 号：R574[医药卫生—消化系统]