Hcy水平对颅内动脉瘤形成及破裂的临床意义  

Clinical significance of Hcy level for the occurrence and rupture of intracranial aneurysms

作　　者：叶林峰 郑叶祥 黄财城 YE Linfeng;ZHENG Yexiang;HUANG Caicheng(Department of Neurology,Ningde Municipal Hospital Affiliated to Ningde Normal University,Ningde 352000,Fujian,China)

机构地区：[1]宁德师范学院附属宁德市医院神经内科,福建宁德352000

出　　处：《中南医学科学杂志》2024年第5期846-849,共4页Medical Science Journal of Central South China

基　　金：宁德师范学院附属宁德市医院科研项目专项(2022X71)。

摘　　要：目的 分析血清同型半胱氨酸(Hcy)水平对颅内动脉瘤形成及破裂的临床意义。方法 选取颅内动脉瘤患者157例为颅内动脉瘤组,根据颅内动脉瘤是否破裂分为非破裂组95例和破裂组62例;另选取同期眩晕综合征和动静脉畸形患者79例为对照组。比较对照组与颅内动脉瘤组临床资料,以及非破裂组与破裂组Hcy、颅内动脉瘤直径。采用Logistic回归分析颅内动脉瘤形成的危险因素;采用Sperman相关性分析Hcy与颅内动脉瘤直径的相关性。结果 对照组与颅内动脉瘤组年龄、高血压、动脉粥样硬化、吸烟占比、Hcy水平比较,差异有显著性(P<0.05)。与非破裂组比较,破裂组Hcy水平显著降低(P<0.001),而颅内动脉瘤直径显著增加(P<0.001)。Logistic回归分析结果显示,Hcy是颅内动脉瘤形成的危险因素(P<0.05)。Hcy水平与颅内动脉瘤直径不存在相关性(P>0.05)。结论 Hcy是颅内动脉瘤形成的独立危险因素,但与颅内动脉瘤破裂无相关性。Aim To analyze clinical significance of serum homocysteine(Hcy) level for the occurrence and rupture of intracranial aneurysms.Methods 157 cases of intracranial aneurysms in our hospital were selected as the intracranial aneurysms group,and they were divided into 95 non-rupture group and 62 rupture group according to whether or not intracranial aneurysms ruptured.In addition,79 eligible cases of vertigo syndrome and arteriovenous malformation were selected as the control group.Clinical data between the control group and the intracranial aneurysms group,and the Hcy level and diameter of intracranial aneurysms in non-ruptured and ruptured group were compared.The risk factors for the occurrence of intracranial aneurysms were analyzed by using Logistic regression.The correlation between Hcy and intracranial aneurysms diameter was analyzed by Sperman's correlation.Results There were significant differences in age,proportion of hypertension,atherosclerosis,smoking and Hcy level between control group and intracranial aneurysms group(P<0.05).Compared with the non-ruptured group,the Hcy level in the ruptured group was significantly decreased(P<0.001),while the intracranial aneurysms diameter was significantly increased(P<0.001).Logistic regression analysis showed that Hcy was a risk factor for the formation of intracranial aneurysms(P<0.05).There was no correlation between Hcy level and intracranial aneurysms diameter(P>0.05).Conclusion Hcy is an independent risk factor for the formation of intracranial aneurysms,but it is not correlated with the rupture of intracranial aneurysms.

关 键 词：颅内动脉瘤 颅内动脉瘤破裂 同型半胱氨酸 颅内动脉瘤直径 

分 类 号：R743[医药卫生—神经病学与精神病学]