结肠固有层巨噬细胞在溃疡性结肠炎中的作用研究  

Roles study of colonic lamina propria macrophages in ulcerative colitis

作　　者：赵鑫 姜媛 但文利 张慧媛 李娟 施京红 陈丽华 Zhao Xin;Jiang Yuan;Dan Wenli;Zhang Huiyuan;Li Juan;Shi Jinghong;Chen Lihua(College of Medical Technology,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China;Department of Immunology,School of Basic Medical Sciences,Air Force Medical University,Xi′an 710032,China)

机构地区：[1]陕西中医药大学医学技术学院,咸阳712046 [2]空军军医大学基础医学院免疫学教研室,西安710032

出　　处：《中华炎性肠病杂志（中英文）》2024年第4期309-313,共5页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(82071848)。

摘　　要：溃疡性结肠炎(UC)是一种与免疫功能紊乱密切相关的肠道慢性复发性炎性疾病。结肠固有层巨噬细胞是肠黏膜中最为丰富的巨噬细胞群体,能够有效维持和调节肠道内环境的稳定,其介导的炎症反应在UC发生发展中发挥重要作用。本文围绕两种不同亚型的结肠固有层巨噬细胞在UC中的作用机制进行综述,以期为UC的临床治疗提供新思路。Ulcerative colitis(UC)is a chronic relapsing inflammatory disease of the intestine closely associated with immune dysfunction.Colonic lamina propria macrophages are the most abundant population of macrophages in the intestinal mucosa,capable of effectively maintaining and regulating the stability of the intestinal environment.The inflammatory responses mediated by these macrophages play a significant role in the occurrence and development of UC.This article provides a comprehensive review of the roles and mechanisms of two different subtypes of colonic lamina propria macrophages in UC,aiming to provide new insights for the clinical treatment of UC.

关 键 词：溃疡性结肠炎 巨噬细胞 结肠固有层 细胞因子 

分 类 号：R574.62[医药卫生—消化系统]