Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus  

作　　者：Wenlong Li Feishi Shan Qingdong Bao Qinghua Li Hua Gao Leyong Wang 

机构地区：[1]State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao266071,China Eye Hospital of Shandong First Medical University,Ji'nan 250021,China [2]College of Ophthalmology,Shandong First Medical University,Ji'nan 250000,China [3]Key Laboratory of Mesoscopic Chemistry of MOE,Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China [4]State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,Chin [5]Eye Hospital of Shandong First Medical University,Ji'nan 250021,China

出　　处：《Chinese Chemical Letters》2024年第10期1-3,共3页中国化学快报（英文版）

摘　　要：Keratoconus is a clinically prevalent corneal ectasia,characterized by progressive thinning and conical protrusion of the central cornea[1].With an incidence rate of one in every 400 to 2000 individuals,it stands as a leading cause of blindness among the youth.To date,there are no pharmacological interventions available for the treatment of keratoconus.In advanced cases culminating in blindness,corneal transplantation remains the only restorative option.However,this surgical procedure carries risks of immune rejection and chronic graft failure.

关 键 词：CORNEAL TREATMENT GRAFT 

分 类 号：R318[医药卫生—生物医学工程] O641.3[医药卫生—基础医学] TB383.1[理学—物理化学]