Environmentally friendly polylysine gauze dressing for an innovative antimicrobial approach to infected wound management  

作　　者：Yaxian Liang Qingyi Li Liwei Hu Ruohan Zhai Fan Liu Lin Tan Xiaofei Wang Huixu Xie 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China College of Stomatology,Sichuan University,Chengdu 610041,China [2]College of Biomass Science and Engineering,Key Laboratory of Biomass Fibers for Medical Care in Textile Industry,Sichuan University,Chengdu 60065,China [3]Division of Thyroid Surgery,Department of General Surgery,Laboratory of Thyroid and Parathyroid Disease,Frontiers Science Center for Disease-Related Molecular Network,West China Hospital,Sichuan University.Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2024年第10期309-314,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82370977,52073186);Medical Science and Technology Project of Sichuan Provincial Health Commission(No.21PJ059);Science and Technology Application Fundamental Project of Sichuan Province(No.2022YFS0124);Funding for Distinguished Young Scholars of Sichuan Province(No.23NSFJQ0001);Strategic Cooperation Projects of Yi Bin City and Sichuan University(No.2020CDYB-6)。

摘　　要：Infections frequently occur after skin injuries,posing a significant challenge in current clinical care.Frequently changing dressings to minimize wound infections and adhesions results in large amounts of medical waste.Therefore,developing environmentally friendly multifunctional dressings has considerable application and translational significance.This study aimed to prepare a wound dressing with favorable antimicrobial properties and biosafety by grafting a natural antimicrobial peptide,polylysine,onto a traditional cotton textile dressing.The cotton textile dressing offers excellent moisture absorption and softness,while polylysine provides excellent biocompatibility,a broad antimicrobial spectrum,and high stability.Furthermore,both materials are natural and biodegradable,making them ideal for environmentally friendly wound dressings.

关 键 词：POLYLYSINE Modified cotton dressing ANTIMICROBIAL Environmentally friendly Infected wound management 

分 类 号：TS106.67[轻工技术与工程—纺织工程] R318.08[轻工技术与工程—纺织科学与工程]