神经突方向离散度与密度成像对颞叶癫痫患者海马亚区的研究  

Study of hippocampal subregion in patients with temporal lobe epilepsy by neurite orientation dispersion and density imaging

作　　者：杨文蕊 王旭聪 李健 闫梦楠 李金芹 张彦玲 陈兵[1] YANG Wenrui;WANG Xucong;LI Jian;YAN Mengnan;LI Jinqin;ZHANG Yanling;CHEN Bing(Department of Radiology,General Hospital of Ningria Medical University,Yinchuan 750004,China;Ningria Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院放射科,宁夏银川750004 [2]宁夏医科大学,宁夏银川750004

出　　处：《实用放射学杂志》2024年第9期1403-1407,共5页Journal of Practical Radiology

基　　金：宁夏医科大学总医院新入职硕士人才培养项目([2023]394号)。

摘　　要：目的 利用神经突方向离散度与密度成像(NODDI)探讨单侧颞叶癫痫(TLE)患者海马(HC)微结构的变化.方法 计算颞叶癫痫合并海马硬化(TLE-HS)患者、非HS(non-HS)患者以及健康对照(对照组)HC整体与HC亚区NODDI指标.比较3组间和组内的NODDI指标差异,并将差异指标与患者的临床发病特征做相关性分析.结果 共纳入47例TLE患者(27例TLE-HS,20例non-HS)与22例健康对照.TLE-HS组组内比较,患侧HC及齿状回颗粒细胞层(GC-DG)亚区各向同性水分子体积分数(fiso)值显著高于对侧;CA1和CA4亚区方向离散度指数(ODI)值显著低于对侧;患侧HC、CA1、CA2~3、CA4及GC-DG亚区神经突密度指数(NDI)值显著降低.non-HS组患侧与对侧无显著差异.组间比较,TLE-HS组患侧HC及GC-DG亚区fiso值显著高于对照组;TLE-HS组患侧HC CA1亚区ODI值显著低于对照组和non-HS组;TLE-HS组患侧HC及下托(Sub)、CA1、CA4、GC-DG亚区NDI值显著低于对照组,non-HS组患侧HC及CA1、CA4、GC-DG亚区NDI值显著低于对照组.TLE-HS组患侧HC CA4亚区的NDI值与病程呈负相关,其他亚区变量与病程、发病频率及单次发病持续时间之间无明确相关性.结论 NODDI技术具有检测TLE患者HC微结构变化的能力,其中NDI更能突出TLE患者的神经元损伤和纤维重组.Objective To explore the hippocampal(HC)microstructural changes in patients with unilateral temporal lobe epilepsy(TLE)by neurite orientation dispersion and density imaging(NODDI).Methods The NODDI indexes of the whole HC and HC subregions of temporal lobe epilepsy with hippocampal sclerosis(TLE-HS)patients,non-HS patients and healthy controls(control group)were calculated.The differences of NODDI indexes among and within the three groups were compared,and the correlation between the difference indexes and the clinical characteristics of the patients was analyzed.Results A total of 47 patients with TLE(27 cases of TLE-HS,2o cases of non-HS)and 22 cases of healthy controls were enrolled.In the TLE-HS group,the free-water isotropic vol-ume fraction(fiso)values of the HC and granular cell layer of dentate gyrus(GC-DG)subregions of the affected side were signifi-cantly higher than those of the contralateral side;the orientation dispersion index(ODI)values of the CAl and CA4 subregions were significantly lower than those of the contralateral side;and the neurite density index(NDI)values of the HC,CA1,CA2-3,CA4 and GC-DG subregions of the affected side decreased significantly.There was no significant difference between the affected side and the contralateral side in the non-HS group.The fiso values of the HC and GC-DG subregions of the affected side in the TLE-HS group were significantly higher than those in the control group,the ODI values of the HC CAl subregions of the affected side in the TLE-HS group were significantly lower than those in the control group and the non-HS group,the NDI values of the HC and subiculum(Sub),

关 键 词：颞叶癫痫 海马硬化 神经突方向离散度与密度成像 神经突密度指数 方向离散度指数 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R742[医药卫生—临床医学] R445.2