淫羊藿醇提物及其热裂解产物的挥发性成分研究  

Study on the volatile components of Epimedium extract and its pyrolysis products

作　　者：刘凌润 田时玲 吴昌健 陈蕊 叶远青 秦艳华[3] 殷志琦[2] 曹毅[3] 张健[1] LIU Ling-run;TIAN Shi-ling;WU Chang-jian;CHEN Rui;YE Yuan-qing;QIN Yan-hua;YIN Zhi-qi;CAO Yi;ZHANG Jian(School of Third Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China;China Tobacco Jiangsu Industrial Co.,Ltd.,Nanjing 210019,China)

机构地区：[1]南京中医药大学第三临床医学院,南京210028 [2]中国药科大学中药学院,南京210009 [3]江苏中烟工业有限责任公司,南京210019

出　　处：《药物分析杂志》2024年第9期1485-1496,共12页Chinese Journal of Pharmaceutical Analysis

基　　金：江苏中烟工业有限责任公司科技项目(H202203)。

摘　　要：目的:研究淫羊藿醇提物的香味成分以及对淫羊藿醇提物进行热裂解产物分析。方法:采用电子鼻对淫羊藿醇提物挥发性成分进行分析;通过正交试验优化淫羊藿醇提工艺;采用热重-气质联用分析仪(TG-GC-MS),模拟卷烟燃烧过程,分析淫羊藿醇提物浸膏在氮气环境中的裂解产物,并对其裂解机制进行推测。结果:各浓度乙醇提取的淫羊藿醇提物共检测出22个挥发性成分,60%浓度的乙醇提取的淫羊藿优于其他浓度;淫羊藿浸膏裂解产物在150、300、450℃共鉴定出78个化合物,包括醛、酮、醇、酚、呋喃类化合物及芳香族化合物等香气成分。结论:淫羊藿醇提物本身含有许多香味挥发性成分,在热裂解后产生大量酮、醇、酚、呋喃类等挥发性香气化合物。Objective:To investigate the flavor components of Epimedium extract and analyze pyrolysis products of the extracts from Epimedium.Methods:Ultra fast gas phase electronic nose was adopted to analyze volatile components in ethanol extracts of Epimedium and the alcohol extracting process of Epimedium was optimized by orthogonal experiment.Epimedium extract was pyrolysed to simulate cigarette smoking by TG-GC-MS.The lysates of Epimedium extract were analysed in a nitrogen environment,and the possible lysate mechanism of the products was reasonably speculated.Results:22 volatile components were detected in the ethanol extracts of Epimedium at different concentrations.Concentration of Epimedium extracted with 60%ethanol was superior than others.Analyzing pyrolysis products of Epimedium extract,78 compounds were identified at 150,300 and 450℃,including aldehydes,ketones,alcohols,phenols,furans and benzene series.Conclusion:Ethanol extraction of Epimedium contains many aromatic volatile components.A large number of ketones,alcohols,phenols,furans and other volatile aroma compounds are produced after pyrolysis of Epimedium extract.

关 键 词：淫羊藿 电子鼻 挥发性成分 正交实验 热重-气质联用 热裂解 

分 类 号：R917[医药卫生—药物分析学]