肝细胞癌微血管侵犯术前预测的研究进展  

Advances in preoperative predictive indicators for microvascular invasion in hepatocellular carcinoma

作　　者：单思乔 王思远 杨栋良 姜楠[1] 林铭宇 张韬 袁雪丽[1] 金烁 曾建平[1] Shan Siqiao;Wang Siyuan;Yang Dongliang;Jiang Nan;Lin Mingyu;Zhang Tao;Yuan Xueli;Jin Shuo;Zeng Jianping(Hepatopancreatobiliary Center,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China;Department of Hepatobiliary and Pancreatic Surgery,General Surgery Center,First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]清华大学附属北京清华长庚医院肝胆胰中心、清华大学临床医学院,北京102218 [2]吉林大学第一医院普通外科中心肝胆胰外科,长春130021

出　　处：《中华肝胆外科杂志》2024年第9期705-709,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：清华大学精准医学科研计划(10001020123、2022TS014);北京医师科学家计划扬帆计划(YGLX202329);北京清华长庚医院研究基金(12023C01004)。

摘　　要：肝细胞癌有术后高复发率、高致死率等特点。研究显示肝细胞癌微血管侵犯(MVI)与术后早期复发与转移存在联系,影响患者预后。术前预测MVI成为肝细胞癌新的研究方向。术前精准预测MVI有助于预先实施相关干预(诸如扩大切除范围等),实现患者受益最大化。本文基于肝细胞癌的生物学特征、基因测定、影像学与肿瘤标志物四个维度总结MVI术前预测的研究现状。Hepatocellular carcinoma(HCC)is characterized by high postoperative recurrence and mortality rates.In recent years,researchers have identified a significant correlation between microvascular invasion(MVI)and early postoperative recurrence and metastasis of HCC,making it a focal point of HCC research.Accurate preoperative prediction of MVI occurrence and the implementation of relevant interventions(such as expanded resection)could provide substantial benefits to patients.This study analyzes global research over the past decade on MVI predictive indicators based on tumor biological characteristics,genetic measurements,imaging examinations,and tumor markers.The aim is to use these predictive indicators to objectively forecast the occurrence of MVI,thereby aiding in preoperative individual assessments and enhancing treatment plans.

关 键 词：癌 肝细胞 微血管侵犯 预测指标 

分 类 号：R735.7[医药卫生—肿瘤]