胸外侧动脉彩色多普勒超声血流参数及血清VEGF、HAS2水平联合检测对乳腺癌术后患者复发转移的预测价值  

Predictive value of combined detection of color Doppler ultrasound blood flow parameters of lateral thoracic artery and serum VEGF and HAS2 levels for recurrence and metastasis of postoperative patients with breast cancer

作　　者：袁梅 孙改艳 刘芳 YUAN Mei;SUN Gaiyan;LIU Fang(Department of Ultrasound of the First People’s Hospital of Xiangfu District of Kaifeng City,Kaifeng 475100 Henan,China;Department of Ultrasound of Kaifeng Central Hospital,Kaifeng 475000 Henan,China)

机构地区：[1]开封市祥符区第一人民医院超声科,河南开封475100 [2]开封市中心医院超声科,河南开封475000

出　　处：《中国民康医学》2024年第20期123-125,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨胸外侧动脉(LTA)彩色多普勒超声血流参数及血清血管内皮生长因子(VEGF)、透明质酸合成酶2(HAS2)水平联合检测对乳腺癌术后患者复发转移的预测价值。方法:回顾性分析2022年5月至2023年6月该院收治的63例行根治术的乳腺癌患者的临床资料,根据出院后随访6个月是否出现复发转移分为预后良好组(n=50)和预后不良组(n=13),比较两组LTA彩色多普勒超声血流参数及VEGF、HAS2水平,并绘制受试者工作特征(ROC)曲线分析其对乳腺癌术后患者复发转移的预测价值。结果:预后不良组阻力指数(RI)、搏动指数(PI)和收缩末期峰值/舒张末期峰值(S/D)均低于预后良好组,差异有统计学意义(P<0.05);预后不良组血清VEGF、HAS2水平均高于预后良好组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,RI、PI、S/D及血清VEGF、HAS2水平单项及联合检测预测乳腺癌术后患者复发转移的曲线下面积分别为0.746、0.797、0.818、0.758、0.738、0.932,联合检测预测价值高于各指标单项检测。结论:LTA彩色多普勒超声血流参数及血清VEGF、HAS2水平联合检测预测乳腺癌术后患者复发转移的价值高于各指标单项检测。Objective:To investigate predictive value of combined detection of color Doppler ultrasound blood flow parameters of lateral thoracic artery(LTA)and serum levels of vascular endothelial growth factor(VEGF)and hyaluronic acid synthase 2(HAS2)for recurrence and metastasis in postoperative patients with breast cancer.Methods:The clinical data of 63 patients with breast cancer who underwent radical mastectomy in this hospital from May 2022 to June 2023 were retrospectively analyzed.These patients were divided into good prognosis group(n=50)and poor prognosis group(n=13)according to whether there was recurrence and metastasis after 6 months of follow-up.The LTA color Doppler ultrasound blood flow parameters and the serum levels of VEGF and HAS2 were compared between the two groups.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value for recurrence and metastasis of the postoperative patients with breast cancer.Results:The resistance index(RI),pulsatility index(PI)and end-systolic peak/end-diastolic peak(S/D)in the poor prognosis group were lower than those in the good prognosis group,and the differences were statistically significant(P<0.05).The levels of serum VEGF and HAS2 in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).The ROC curve showed that the area under the curve of single and combined detection of RI,PI,S/D,serum VEGF and HAS2 levels for predicting recurrence and metastasis of the postoperative patients with breast cancer were 0.746,0.797,0.818,0.758,0.738 and 0.932,respectively.The predictive value of combined detection was higher than that of single detection.Conclusions:The value of combined detection of LTA color Doppler ultrasound blood flow parameters and serum VEGF and HAS2 levels in the prediction of recurrence and metastasis of the postoperative patients with breast cancer is higher than that of single detection.

关 键 词：胸外侧动脉 彩色多普勒超声 透明质酸合成酶2 血管内皮生长因子 乳腺癌 根治术 复发转移 

分 类 号：R737.9[医药卫生—肿瘤]