胃苏颗粒联合含铋剂四联疗法治疗老年幽门螺杆菌阳性胃溃疡患者的效果  

Weisu Granule Combined with Bismuth-containing Quadruple Therapy in Elderly Patients with Helicobacter Pylori Positive Gastric Ulcer

作　　者：张慧才 叶社俊 叶眉眉 ZHANG Hui-cai;YE She-jun;YE Mei-mei(Department of Gastroenterology,Shangrao Central Hospital,Shangrao 334000,China)

机构地区：[1]上饶市中心医院消化内科,江西上饶334000

出　　处：《实用临床医学（江西）》2024年第5期20-23,共4页Practical Clinical Medicine

摘　　要：目的探讨胃苏颗粒联合含铋剂四联疗法在老年幽门螺杆菌(Hp)阳性胃溃疡患者中的应用效果。方法选取2022年7月至2023年10月上饶市中心医院收治的86例老年Hp阳性胃溃疡患者,按随机数字表法分为对照组和观察组,各43例。对照组给予铋剂四联疗法,观察组在对照组治疗基础上加用胃苏颗粒,治疗8周。对比2组临床疗效、症状评分、炎症因子[白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平、胃黏膜功能[胃泌素(GAS)、胃蛋白酶原Ⅰ(PGⅠ)及胃蛋白酶原Ⅱ(PGⅡ)水平]、Hp清除率及不良反应。结果观察组总有效率高于对照组(93.35%vs 81.40%,P<0.05)。观察组症状评分[(2.58±0.30)分vs(3.27±0.45)分]、IL-6[(15.23±2.04)pg·mL^(-1) vs(18.41±2.15)pg·mL^(-1)]、CRP[(5.33±1.03)mg·L^(-1) vs(6.86±1.12)mg·L^(-1)]、TNF-α[(28.68±2.15)pg·mL^(-1) vs(33.17±2.89)pg·mL^(-1)]、GAS[(92.96±5.42)ng·L^(-1) vs(105.46±8.33)ng·L^(-1)]水平低于对照组(P<0.05);PGⅠ[(132.85±15.16)μg·L^(-1)vs(103.84±14.50)μg·L^(-1)]、PGⅡ[(10.68±1.21)μg·L^(-1)vs(9.13±0.72)μg·L^(-1)]水平高于对照组(P<0.05)。Hp清除率高于对照组(93.02%vs 76.74%,P<0.05)。2组不良反应发生率比较差异无统计学意义[6.98%(3/43)vs 9.30%(3/43)](P>0.05)。结论胃苏颗粒联合含铋剂四联疗在Hp阳性胃溃疡中治疗效果显著,可增强Hp清除率,减轻炎症,保护胃黏膜,促进症状消退,安全有效。Objective To investigate clinical effect of Weisu granule combined with bismuth-containing quadruple therapy in the management helicobacter pylori(Hp)positive gastric ulcer among elderly patients.Methods A total of 86 elderly patients with Hp-positive gastric ulcer admitted to Shangrao Central Hospital from July 2022 to October 2023 were selected and divided into a control group and an observation group,using the random number table method,with 43 patients in each group.The control group was given bismuth-containing quadruple therapy,whereas the observation group was administered with Weisu granules on the basis of the control group’s treatment,both for a duration of 8 weeks.Clinical efficacy,symptom scores,levels of inflammatory cytokines[interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)],gastric mucosal function[gastrin(GAS),pepsinogenⅠ(PGⅠ),and pepsinogenⅡ(PGⅡ)levels],Hp clearance rate,and adverse reactions were compared between the 2 groups.Results The total effective rate in the observation group was higher than that in the control group(93.35%vs 81.40%,P<0.05).Compared to the control group,the observation group had lower symptom scores[(2.58±0.30)vs(3.27±0.45)],lower levels of IL-6[(15.23±2.04)pg·mL^(-1) vs(18.41±2.15)pg·mL^(-1)],CRP[(5.33±1.03)mg·L^(-1) vs(6.86±1.12)mg·L^(-1)],and TNF-α[(28.68±2.15)pg·mL^(-1) vs(33.17±2.89)pg·mL^(-1)],and lower levels of GAS[(92.96±5.42)ng·L^(-1) vs(105.46±8.33)ng·L^(-1)](P<0.05);the levels of PGⅠand PGⅡwere higher in the observation group than those in the control group(P<0.05),(132.85±15.16)μg·L^(-1) vs(103.84±14.50)μg·L^(-1) and(10.68±1.21)μg·L^(-1) vs(9.13±0.72)μg·L^(-1),respectively;Hp clearance rate was higher in the observation group than that in the control group(93.02%vs 76.74%,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the control group and the observation group[6.98%(3/43)vs 9.30%(4/43)](P>0.05).Conclusion Weisu granule combine

关 键 词：胃溃疡 幽门螺杆菌 胃苏颗粒 铋剂四联疗法 临床疗效 炎症水平 

分 类 号：R573.1[医药卫生—消化系统]