复方氯己定含漱液联合替硝唑治疗牙周病的效果观察  

Observation on the Effectiveness of Compound Gargle Solution Chlorhexidine Gluconaie Combined with Tinidazolein the Treatment of Periodontal Disease

作　　者：戴玉平 李丽 肖晓芳 刘天虹[3] DAI Yuping;LI Li;XIAO Xiaofang;LIU Tianhong(Department of Stomatology,Ji'an First People's Hospital,Ji'an 343000,Jiangxi,China;Department of Administrative Office,Ji'an First People's Hospital,Ji'an 343000,Jiangxi,China;Department of Obstetrics and Gynecology,Ji'an First People's Hospital,Ji'an 343000,Jiangxi,China)

机构地区：[1]吉安市第一人民医院口腔科,江西吉安343000 [2]吉安市第一人民医院行政办公室,江西吉安343000 [3]吉安市第一人民医院妇产科,江西吉安343000

出　　处：《医学信息》2024年第20期116-119,共4页Journal of Medical Information

基　　金：江西省吉安市科技计划指导性项目(编号:20233-043874)。

摘　　要：目的探讨复方氯己定含漱液联合替硝唑治疗牙周病的有效性。方法选取2021年1月-2023年6月在吉安市第一人民医院接受治疗的82例牙周病患者作为研究对象,采用1∶1随机分为参照组和研究组,每组41例。参照组单独采用替硝唑治疗,研究组复方氯己定含漱液联合替硝唑治疗,比较两组患者牙周指标(牙周附着指数、牙菌斑指数、牙龈指数和牙齿松动度)、口腔健康质量评分(功能限制、生理性疼痛、心理不适、生理障碍、心理障碍、社交障碍和残障)、龈沟液相关炎性水平[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]及临床疗效。结果研究组牙周附着指数、牙菌斑指数、牙龈指数、牙齿松动度低于参照组(P<0.05);研究组口腔健康质量评分低于参照组(P<0.05);研究组TNF-α、IL-6、hs-CRP水平均低于参照组(P<0.05);研究组治疗总有效率高于参照组(P<0.05)。结论复方氯己定含漱液联合替硝唑治疗牙周病患者的效果确切,能够减轻口腔炎症,改善口腔健康状况和牙周各项临床指标,值得临床应用。Objective To investigate the effectiveness of compound gargle solution chlorhexidine gluconaie combined with tinidazole in the treatment of periodontal disease.Methods A total of 82 patients with periodontal disease who received treatment in Ji'an First People's Hospital of Jiangxi Province from January 2021 to June 2023 were selected as the study objects and randomly divided into the reference group and the study group 1∶1,with 41patients in each group.The reference group was treated with tinidazole alone,and the study group was treated with compound gargle solution chlorhexidine gluconaie combined with tinidazole.The periodontal indexes(periodontal attachment index,plaque index,gingival index and tooth mobility),oral health quality score(functional limitation,physiological pain,psychological discomfort,physiological disorder,psychological disorder,social disorder and disability),gingival crevicular fluid-related inflammatory levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)]and clinical efficacy were compared between the two groups.Results The periodontal attachment index,plaque index,gingival index and tooth mobility of the study group were lower than those of the reference group(P<0.05).The oral health quality score of the study group was lower than that of the reference group(P<0.05).The levels of TNF-α,IL-6 and hs-CRP in the study group were lower than those in the reference group(P<0.05).The total effective rate of treatment in the study group was higher than that in the reference group(P<0.05).Conclusion Compound gargle solution chlorhexidine gluconaie combined with tinidazole is effective in the treatment of patients with periodontal disease,which can reduce oral inflammation,improve oral health status and periodontal clinical indicators,and is worthy of clinical application.

关 键 词：牙周病 复方氯己定含漱液 替硝唑 口腔炎症 

分 类 号：R781.4[医药卫生—口腔医学]