眼表超声雾化、睑板腺镊按摩及聚乙二醇滴眼联合治疗MGD相关干眼的临床研究  

Clinical Study on the Combined Treatment of MGD-Related Dry Eye with Ocular Surface Ultrasonic Atomization,Meibomian Gland Forcep Massage,and Polyethylene Glycol Eye Drop

作　　者：刘盛春 王利群 王新[1] LIU Shengchun;WANG Liqun;WANG Xin(The First People's Hospital of Longquanyi District Chengdu,Sichuan Chengdu 610100)

机构地区：[1]成都市龙泉驿区第一人民医院,四川成都610100

出　　处：《深圳中西医结合杂志》2024年第16期20-23,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：成都市卫生健康委员会医学科研课题项目(2019032)。

摘　　要：目的:分析眼表超声雾化+睑板腺镊按摩+聚乙二醇滴眼液治疗睑板腺功能障碍(MGD)相关干眼的临床效果。方法:选取在成都市龙泉驿区第一人民医院眼科门诊2019年7月至2021年6月首次就诊的80例MGD相关干眼患者作为研究对象,根据随机数字表法将患者分为对照组[40例(80眼),热敷+手指睑板腺按摩+聚乙二醇滴眼液治疗]和观察组[40例(80眼),眼表超声雾化+睑板腺镊按摩+聚乙二醇滴眼液治疗],比较不同方案的临床效果。结果:治疗4周后,相比于对照组,观察组患者眼表疾病指数问卷(OSDI)评分、角膜荧光素染色评分、睑脂排出能力评分、睑板腺分泌物性状评分较低,泪膜破裂时间较长,差异具有统计学意义(P<0.05);两组患者治疗过程中均未发生严重眼部并发症;观察组患者治疗总有效率为95.00%,较对照组的80.00%更高,差异具有统计学意义(P<0.05)。结论:眼表超声雾化、睑板腺镊按摩及聚乙二醇滴眼液联合治疗MGD相关干眼,可确切改善眼部不适相关症状,促进睑板腺功能提升,恢复泪液正常分泌,保证临床治疗效果,且联合方案安全性较高。Objective To analyze the clinical effect of ocular surface ultrasonic atomization+meibomian gland forcep massage+polyethylene glycol eye drop on meibomian gland dysfunction(MGD)-related dry eye.Methods A total of 80 MGD-related dry eye patients who first visited the ophthalmology clinic of the First People's Hospital of Longquanyi District Chengdu from July 2019 to June 2021 were selected as the study objects.According to the random number table method,the patients were divided into a control group[40 cases(80 eyes),hot compress+finger meibomian gland massage+polyethylene glycol eye drop treatment]and an observation group[40 cases(80 eyes),ocular surface ultrasonic atomization+meibomian gland forcep massage+polyethylene glycol eye drop treatment],the clinical effects of different schemes were compared.Results After 4 weeks of treatment,compared with the control group,the observation group had lower scores of ocular surface disease index questionnaire(OSDI),corneal fluorescein staining,palpebral lipid excretion ability and meibomian gland secretion character,and the tear film rupture time was longer,with statistical significances(P<0.05).No serious eye complications occurred in both groups during treatment.The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of ocular surface ultrasonic atomization,meibomian gland forcep massage and polyethylene glycol eye drop in the treatment of MGD-related dry eye can accurately improve the symptoms of eye discomfort,promote the improvement of meibomian gland function,restore the normal secretion of tears,and ensure the clinical treatment effect,and the combined program is relatively safe.

关 键 词：睑板腺功能障碍相关干眼 眼表超声雾化 睑板腺镊按摩 聚乙二醇滴眼液 

分 类 号：R777.1[医药卫生—眼科]