卡马西平对新诊断部分性癫痫的疗效及对TLR-4、NF-κB水平的影响  

The Effect of Carbamazepine on Newly Diagnosed Partial Epilepsy and Its Influence on TLR-4 and NF-κB

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作  者:王帅 常璐 王旗 WANG Shuai;CHANG Lu;WANG Qi(Nanyang Central Hospital,Henan Nanyang 473000)

机构地区:[1]南阳市中心医院,河南南阳473000

出  处:《深圳中西医结合杂志》2024年第16期112-114,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘  要:目的:分析卡马西平(CBZ)治疗新诊断部分性癫痫患者的效果以及其对患者血清Toll样受体–4(TLR–4)、核转录因子–κB(NF–κB)水平的影响。方法:将南阳市中心医院新诊断的部分性癫痫患者81例(选取时间为2022年3月至2023年11月)以掷硬币法分为观察组(41例)和对照组(40例)。对照组采用托吡酯治疗,观察组在对照组基础上增加应用CBZ治疗。比较两组患者的临床疗效、治疗前后的TLR–4、NF–κB水平以及治疗期间的不良反应发生情况。结果:观察组患者临床总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后3个月,观察组患者TLR–4与NF–κB水平低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:应用CBZ对新诊断部分性癫痫患者的疗效良好,有利于降低患者血清中的TLR–4、NF–κB水平,且该药物安全性尚可。Objective To analyze the efficacy of carbamazepine(CBZ)in the treatment of patients with newly diagnosed partial epilepsy and its effect on serum toll-like receptor 4(TLR-4)and nuclear factor-κB(NF-κB)levels.Methods Eighty-one patients with newly diagnosed partial epilepsy in Nanyang Central Hospital(selected from March 2022 to November 2023)were divided into an observation group(41 cases)and a control group(40 cases)by coin toss method.The control group was treated with topiramate,and the observation group was additionally treated with CBZ on the basis of the control group.The clinical efficacy,TLR-4,NF-κB levels before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).At 3 months after treatment,the levels of TLR-4 and NF-κB in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion CBZ has a good effect on patients with newly diagnosed partial epilepsy,and can help to reduce the levels of TLR-4 and NF-κB in the serum of patients,and the drug is safe.

关 键 词:新诊断部分性癫痫 卡马西平 Toll样受体–4 核转录因子–κB 

分 类 号:R742.1[医药卫生—神经病学与精神病学]

 

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