肺癌患者血清IL-1β、CAR及HBP水平与化疗期间继发肺部白色假丝酵母菌感染的关系  

Relationship between serum IL-1β,CAR,and HBP levels and secondary pulmonary Candida albicans infection during chemotherapy in patients with lung cancer

作　　者：宋静静 王缚鲲 张会峰 刘叶 蒋梦雨 安黎云 SONG Jingjing;WANG Fukun;ZHANG Huifeng;LIU Ye;JIANG Mengyu;AN Liyun(Department of Clinical Laboratory,the 980th Hospital of People′s Liberation Army of China Joint Logistics Support Forces,Shijiazhuang,Hebei 050082,China)

机构地区：[1]中国人民解放军联勤保障部队第九八〇医院检验科,河北石家庄050082

出　　处：《国际检验医学杂志》2024年第20期2456-2460,共5页International Journal of Laboratory Medicine

基　　金：2018年度河北省医学科学研究重点课题计划(20180919)。

摘　　要：目的探讨肺癌患者血清白细胞介素-1β(IL-1β)、C反应蛋白与白蛋白比值(CAR)及肝素结合蛋白(HBP)水平与化疗期间继发肺部白色假丝酵母菌感染的关系。方法选取2018年1月至2022年4月该院收治的肺癌患者175例,均予以化疗方案,根据其是否继发肺部白色假丝酵母菌感染分为感染组(37例)与非感染组(138例)。比较两组临床资料、血清IL-1β、HBP水平及CAR,采用多因素Logistic回归分析肺癌患者化疗期间继发肺部白色假丝酵母菌感染的影响因素,采用受试者工作特征(ROC)曲线分析血清IL-1β、CAR、HBP对化疗期间继发肺部白色假丝酵母菌感染的预测价值,比较不同血清IL-1β、HBP水平及CAR的肺癌患者预后情况。结果感染组吸烟、病理分期、糖尿病、化疗周期、慢性阻塞性肺疾病、解剖部位与非感染组比较,差异有统计学意义(P<0.05);感染组血清IL-1β、HBP水平及CAR均高于非感染组(P<0.05);多因素Logistic回归分析结果显示,吸烟、糖尿病、解剖部位、慢性阻塞性肺疾病、病理分期、化疗周期及血清IL-1β、HBP、CAR均为肺癌患者化疗期间继发肺部白色假丝酵母菌感染的影响因素(P<0.05)。血清IL-1β、CAR、HBP单独预测肺部白色假丝酵母菌感染的曲线下面积(AUC)分别为0.779、0.732、0.796,三者联合预测的AUC为0.931,灵敏度、特异度分别为86.49%、90.58%;IL-1β、CAR、HBP高水平亚组的肺癌患者生存率明显低于低水平亚组(P<0.05)。结论肺癌患者血清IL-1β、HBP水平及CAR升高与化疗期间继发肺部白色假丝酵母菌感染有关,检测其水平有助于预测肺部白色假丝酵母菌感染及死亡风险。Objective To investigate the relationship between serum interleukin-1β(IL-1β),C-reactive protein to albumin ratio(CAR)and heparin-binding protein(HBP)levels and secondary pulmonary Candida albicans infection during chemotherapy in patients with lung cancer.Methods A total of 175 patients with lung cancer admitted to this hospital from January 2018 to April 2022 were selected,and all patients were treated with chemotherapy.According to whether they had secondary pulmonary Candida albicans infection,they were divided into infection group(37 cases)and non-infection group(138 cases).The clinical data,serum levels of IL-1β,HBP and CAR were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of secondary pulmonary Candida albicans infection in patients with lung cancer during chemotherapy.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum IL-1β,CAR and HBP for secondary pulmonary Candida albicans infection during chemotherapy,and the prognosis of lung cancer patients with different serum IL-1β,HBP levels and CAR were compared.Results There were significant differences in smoking,pathological stage,diabetes mellitus,chemotherapy cycle,chronic obstructive pulmonary disease and anatomical location between the infection group and the non-infection group(P<0.05).The serum levels of IL-1β,HBP and CAR in the infection group were higher than those in the non-infection group(P<0.05).Multivariate Logistic regression analysis showed that smoking,diabetes,anatomical site,chronic obstructive pulmonary disease,pathological stage,chemotherapy cycle and serum IL-1β,HBP,CAR were the influencing factors of secondary pulmonary Candida albicans infection in patients with lung cancer during chemotherapy(P<0.05).The area under the curve(AUC)of serum IL-1β,CAR and HBP in predicting pulmonary Candida albicans infection was 0.779,0.732 and 0.796,respectively.The AUC of the combination of the three was 0.931,and the sensitivi

关 键 词：肺癌 肺部感染 白细胞介素-1Β C反应蛋白与白蛋白比值 白色假丝酵母菌 肝素结合蛋白 

分 类 号：R734.2[医药卫生—肿瘤]