D型单端孢霉烯类化合物及其抗癌活性研究进展  

Research progress on D-type trichothecenes and their anticancer activity

作　　者：朱登高 胡嘉瑶 肖健 王晓玲 林利彬 ZHU Deng-gao;HU Jia-yao;XIAO Jian;WANG Xiao-ling;LIN Li-bin(Shaanxi Key Laboratory of Phytochemistry,College of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji 721013,Shaanxi,China)

机构地区：[1]宝鸡文理学院化学化工学院,陕西省植物化学重点实验室,陕西宝鸡721013

出　　处：《宝鸡文理学院学报（自然科学版）》2024年第3期11-21,共11页Journal of Baoji University of Arts and Sciences(Natural Science Edition)

基　　金：陕西省科技厅自然科学青年项目(2024JC-YBQN-0782);陕西省教育厅自然科学项目(23JK0284);宝鸡文理学院高层次及博士人才科研启动专项(209040134)。

摘　　要：目的简要综述D型单端孢霉烯类化合物及其抗癌活性的研究现状,为开发新抗癌药物提供先导化合物。方法参考近年来已报道的相关文献,对D型单端孢霉烯类化合物及其抗癌活性进行综述。结果概述了单端孢霉烯类化合物的结构特征,并总结了已报道的D型单端孢霉烯类化合物及其抗癌活性。结论综述了97个D型单端孢霉烯类化合物及其抗癌活性,初步讨论了部分化合物的构效关系,为进一步开发此类小分子用于癌症的治疗奠定基础。Purposes—To briefly summarize the research status of D-type trichothecenes and their anticancer activity,and to provide lead compounds for the development of new anticancer drugs.Methods—The D-type trichothecenes and their anticancer activities were reviewed by reference to relevant literature reported in recent years.Results—The structural features of trichothecenes are sketched out and the reported D-type trichothecenes and their anticancer activities are summarized.Conclusions—97 D-type trichothecenes and their anticancer activities are reviewed hereof,with the structure-activity relationship of some compounds preliminarily discussed,thus laying the foundation for further development of such small molecules for the treatment of cancer.

关 键 词：共生真菌 D型单端孢霉烯 抗癌活性 

分 类 号：O629.9[理学—有机化学]