不同分子亚型肝细胞腺瘤影像学表现  

Evaluation of imaging differences in different molecular subtypes of hepatocellular adenoma

作　　者：廖忠阳 李杭[2] 陈泳松 LIAO Zhong-yang;LI Hang;CHEN Yong-song(Department of Radiology,Ziyang Third People’s Hospital,Sichuan 641300,China;Sichuan Provincial People’s Hospital,Chengdu 610072,China;First People’s Hospital of Ziyang City(Affiliated Hospital of West China Hospital),Sichuan 641399,China)

机构地区：[1]资阳市第三人民医院放射科,四川641300 [2]四川省人民医院,610072 [3]资阳市第一人民医院(华西医院附属医院),641399

出　　处：《肝脏》2024年第8期960-964,共5页Chinese Hepatology

基　　金：四川省科技计划重点研发项目(2021YFS0169)。

摘　　要：目的分析不同分子亚型肝细胞腺瘤(HCA)影像学表现差异。方法2015年1月—2022年12月我院诊治的100例HCA患者,根据分子亚型将其分为炎症型HCA(I-HCA,62例)、肝细胞核因子1α失活型HCA(H-HCA,22例)、β-连环蛋白激活型HCA(B-HCA,9例)、未分类型HCA(U-HCA,7例)。行超声、磁共振成像检查,分析不同分子亚型患者的影像学表现差异。结果超声特征显示,不同分子亚型HCA内部回声、血流信号、延迟期增强强度、包膜下增强血管影差异有统计学意义(P<0.05)。经磁共振成像检查,对比不同分子亚型HCA T2WI信号、强化方式、脂肪肝,差异有统计学意义(P<0.05)。结论不同分子亚型HCA的超声表现、磁共振成像表现各不相同,其中I-HCA主要表现为低回声、半环形或环形血流信号、延迟期呈低增强,见包膜下增强血管影,T2WI呈高信号、持续强化,伴有脂肪肝,H-HCA的特征为高回声、动脉期整体高增强,而B-HCA、U-HCA病例数较少,影像表现无明显特异性,需在今后的研究中加以完善。Objective To analyze the differences in imaging manifestations of different molecular subtypes of hepatocellular adenoma(HCA).Methods From January 2015 to December 2022,100 HCA patients diagnosed and treated in our hospital were divided into inflammatory HCA(I-HCA,62 cases)and liver cell nuclear factor 1 based on their molecular subtypes α Deactivated HCA(H-HCA,22 cases)β-Chain protein activated HCA(B-HCA,9 cases),unclassified HCA(U-HCA,7 cases).Provide patients with ultrasound and magnetic resonance imaging examinations to analyze the differences in imaging manifestations among patients with different molecular subtypes.Results The ultrasound characteristics showed that there was a statistically significant difference in comparing the internal echoes,blood flow signals,delayed phase enhancement intensity,and subcapsular enhanced vascular shadows of different molecular subtypes of HCA(P<0.05).After magnetic resonance imaging examination,there was a statistically significant difference in T2WI signals,enhancement methods,and fatty liver among different molecular subtypes of HCA(P<0.05).Conclusion The ultrasound and magnetic resonance imaging manifestations of different molecular subtypes of HCA vary.Among them,I-HCA mainly presents as low echo,semi circular or circular blood flow signal,low enhancement in the delay phase,enhancement of blood vessels under the capsule,high signal on T2WI,continuous enhancement,and accompanied by fatty liver.H-HCA is characterized by high echo and overall high enhancement in the arterial phase,while B-HCA and U-HCA have fewer cases and no significant specificity in imaging manifestations,It needs to be improved in future research.

关 键 词：肝细胞腺瘤 分子亚型 影像学表现 

分 类 号：R735.7[医药卫生—肿瘤]