Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients:insight from the ANGEL-ACT registry  

作　　者：Dapeng Sun Xinguang Yang Xiaochuan Huo Raynald- Baixue Jia Xu Tong Anxin Wang Ning Ma Feng Gao Dapeng Mo Zhongrong Miao 

机构地区：[1]Interventional Neuroradiology,Department of Neurology,Beijing Tiantan Hospital,Captial Medical University,Beijing,China [2]Department of Neurology,Sun Yat-Sen Memorial Hospital,Guangzhou,Guangdong,China [3]Cerebrovascular Disease Department,Neurological Disease Center,Beijing Anzhen Hospital,Capital Medical University,Beijing,China [4]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China

出　　处：《Stroke & Vascular Neurology》2024年第3期289-294,I0248-I0250,共9页卒中与血管神经病学（英文）

基　　金：The ANGEL-ACT registry was supported by the National Key Research and Development Program of China,grant number 2016YFC1301500.

摘　　要：Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy(EVT)for acute vertebrobasilar artery occlusion(VBAO).Methods Participants of the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischaemic Stroke(ANGEL-ACT)registry were selected for the analysis.Futile recanalisation was defined as patients did not achieve a 90-day good outcome(modified Rankin Scale≤3)despite successful recanalisation(modified Treatment in Cerebral Ischaemia Scale≥2b)after the procedure.Multivariable logistic regression analysis was conducted to find independent predictors of futile recanalisation in VBAO patients undergoing EVT.Results Three hundred and fifteen patients with VBAO who achieved successful recanalisation after EVT were included in current analysis,of whom,155(49.2%)suffered futile recanalisation,and 160 achieved effective recanalisation.After the multivariable analysis,we found admission National Institutes of Health Stroke Scale(NIHSS)≥19(OR 4.81,95%CI 2.76 to 8.39,p<0.001),platelet-lymphocyte ratio(PLR)≥162.2(OR 1.93,95%CI 1.14 to 3.27,p=0.001),onset-to-puncture time(OTP)≥334min(OR 2.15,95%CI 1.25 to 3.68,p=0.005)and use of general anesthesia(GA)(OR 1.87,95%CI 1.09 to 3.22,p=0.024)were associated with futile recanalisation.Conclusions Futile recanalisation after EVT occurred 49.2%of VBAO patients in the ANGEL-ACT registry.NIHSS≥19,PLR≥162.2,OTP≥334min and use of GA were independent predictors of futile recanalisation.

关 键 词：PATIENTS ANESTHESIA occlusion 

分 类 号：R741[医药卫生—神经病学与精神病学]