Review on carbon dots:Synthesis and application in biology field  

作　　者：Xueting Li Lidong Yu Mingyue He Ce Chen Zewen Yu Shanshan Jiang Yi Wang Li Li Bingsheng Li Guixue Wang Aidong Shen Jianglin Fan 

机构地区：[1]School of Life Science and Technology,Harbin Institute of Technology,Harbin,China [2]School of Physics,Harbin Institute of Technology,Harbin,China [3]College of Basic Medical Sciences,Chongqing Medical University,Chongqing,China [4]Key Laboratory of UV Light Emitting Materials and Technology of Ministry of Education,Northeast Normal University,Changchun,China [5]Key Laboratory for Biorheological Science and Technology,Ministry of Education,State and Local Joint Engineering Laboratory for Vascular Implants,College of Bioengineering,Chongqing University,Chongqing,China [6]Department of Electrical Engineering,The City College of New York,New York,New York,USA [7]Guangdong Province Key Laboratory,Southern China Institute of Large Animal Models for Biomedicine,School of Biotechnology and Health Sciences,Wuyi University,Jiangmen,China

出　　处：《BMEMat(BioMedical Engineering Materials)》2023年第4期65-93,共29页生物医学工程材料（英文）

基　　金：Innovation Team Program of Guangdong Province,Grant/Award Number:2020KCXTD038;Key Technologies Research and Development Program,Grant/Award Number:2019YFA0705202;National Natural Science Foundation of China,Grant/Award Numbers:12032007,31701296,62274027,81941001;Chongqing Natural Science Foundation,Grant/Award Number:cstc2019jcyjzdxmX0028。

摘　　要：As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size, stable chemical properties, excellent photoluminescence characteristics, but also exhibit good biocompatibility and low toxicity. It has attracted considerable attention in the field of nanotechnology and biological science. CDs contain abundant functional groups on the surface, which not only retain part of the properties of raw materials, but also may have new photoelectric, catalytic, biomedical, and other functions. In this review, we systematically summarize the synthesis methods, modifications, optical properties, and main biological functions of CDs in recent years. The application of functionalized modified CDs in biological detection, biological imaging, photodynamic therapy, photothermal therapy, targeted therapy, drug delivery, gene delivery, protein delivery, and other biomedical fields is introduced. The latest progress of CDs with its own biomedical function in antioxidant, anti-pathogen, and disease treatment is summarized. Finally, we discuss some problems in the practical application of CDs and look forward to the future development trend of self-functional CDs combined with surface modification to achieve multimodal treatment of diseases.

关 键 词：anti-COVID-19 ANTI-INFECTION antioxidant BIOIMAGING biosensor carbon dots drug/gene/protein delivery metal detection PDT/PTT self-function subcellular localization 

分 类 号：O64[理学—物理化学]