Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy  

作　　者：Meng Zhang Siyi Ran Xueling Yin Jiting Zhang Xiao Sun Wei Sun Zhihong Zhu 

机构地区：[1]Institute of Nano-Science and Nano-Technology,College of Physical Science and Technology,Central China Normal University,Wuhan,China [2]School of Chemistry and Pharmaceutical Engineering,Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,China [3]Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou,China

出　　处：《BMEMat(BioMedical Engineering Materials)》2023年第4期129-141,共13页生物医学工程材料（英文）

基　　金：Natural Science Foundation of Hubei Province,Grant/Award Number:2019CFB606;National Natural Science Foundation of China,Grant/Award Number:52072139;Innovation Platform for Academicians of Hainan Province。

摘　　要：Destruction of cellular redox homeostasis to induce cancer cell apoptosis is an emerging tumor therapeutic strategy. To achieve this goal, elevating exogenous oxidative stress or impairing the antioxidant defense system of cancer cells is an effective method. Herein, we firstly report a biocompatible and versatile nanoplatform based on mesoporous polydopamine (MpDA) nanoparticles and a phase-change material (PCM) for delivering calcium ascorbate (Vc-Ca), simultaneously enabling combination therapy of hyperthermia, reactive oxygen species (ROS) generation, and suppression of tumor antioxidant capability. In this design, Vc-Ca encapsulated in MpDA using PCM is controllably released due to the melting of PCM matrix in response to photothermal heating upon near-infrared irradiation. Vc-Ca is proved to be a prooxidant that can promote the production of ROS (H2O2) in the tumor site. Remarkably, MpDA can not only act as a photothermal agent but also can break the redox balance of cancer cells through depleting the primary antioxidant glutathione, thus amplifying Vc-Ca-mediated oxidative therapy. Both in vitro and in vivo results demonstrate the significantly enhanced antitumor activity of boosted ROS combined with local hyperthermia. This study highlights the potential applications of Vc-Ca in cancer treatment, and the prepared multifunctional nanoplatform provides a novel paradigm for highefficiency oxidation-photothermal therapy.

关 键 词：calcium ascorbate mesoporous polydopamine nanoparticles oxidative therapy photothermal therapy redox homeostasis 

分 类 号：TB383[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]