Hydrogels for ameliorating osteoarthritis:Mechanical modulation,anti-inflammation,and regeneration  

作　　者：Xuwei Jiang Yuxiang Sun Yuanning Lyu Heemin Kang Jianyang Zhao Kunyu Zhang Liming Bian 

机构地区：[1]School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou,China [2]National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou,China [3]Guangdong Provincial Key Laboratory of Biomedical Engineering,South China University of Technology,Guangzhou,China [4]Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,South China University of Technology,Guangzhou,China [5]Department of Materials Science and Engineering,Korea University,Seoul,Republic of Korea

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第2期34-60,共27页生物医学工程材料（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Number:2022YFB380440003;National Natural Science Foundation of China,Grant/Award Number:32271385;China Postdoctoral Science Foundation,Grant/Award Number:2022M721194。

摘　　要：Osteoarthritis(OA)is a chronic and degenerative disease with limited clinical options for effective suppression.Recently,significant endeavors have been explored to reveal its pathogenesis and develop treatments against OA.Hydrogels,designed with a striking resemblance to the extracellular matrix,offer a biomimetic interaction with biological tissues,presenting a promising avenue for OA amelioration.As a result,biocompatible hydrogels have been erected incorporating on-demand bioactivities to optimize the intra-articular microenvironment,thereby alleviating OA symptoms and fostering the eventual regeneration of articular joints.This review highlights the collaborative objectives underlying the establishment of this tissue microenvironment,encompassing mechanical modulation,anti-inflammation,and tissue regeneration.Specifically,we consolidate recent advances in hydrogel-based biomaterials,serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent-loaded vehicles to combat localized inflammation.Additionally,hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage regeneration.Finally,this review outlines the prospective directions for hydrogel-mediated OA therapies.

关 键 词：cargo-delivery cellular induction HYDROGELS LUBRICATION OSTEOARTHRITIS 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]