Mucoadhesive and antifouling Janus polysaccharide film for prevention of colorectal cancer recurrence post-surgery  

作　　者：Jaebeom Lee Hee Seung Seo Chun Gwon Park Mikyung Shin 

机构地区：[1]Department of Intelligent Precision Healthcare Convergence,Sungkyunkwan University(SKKU),Suwon,Republic of Korea [2]Center for Neuroscience Imaging Research,Institute for Basic Science(IBS),Suwon,Republic of Korea [3]Department of Biomedical Engineering,Sungkyunkwan University(SKKU),Suwon,Republic of Korea [4]Biomaterials Research Center,Korea Institute of Science and Technology,Seoul,Republic of Korea [5]Biomedical Institute for Convergence,Sungkyunkwan University(SKKU),Suwon,Republic of Korea

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第2期134-144,共11页生物医学工程材料（英文）

基　　金：National Research Foundation of Korea,Grant/Award Numbers:2023-00208913,RS-2023-00208262。

摘　　要：Colorectal cancer is one of the most common cancers,and current treatment options include surgery,chemotherapy,and radiation therapy.Most patients undergo surgery,which often requires extensive resection of the colon to prevent recurrence and metastasis of residual malignant tumor cells,leading to postoperative pain and discomfort in daily routines.Although versatile therapeutic patches have been developed to induce tumor apoptosis,achieving both great adhesiveness on the mucus layers of the colon tissue and anti-cell/tissue adhesion to other surrounding organs remains a challenge.Herein,we report a Janus polysaccharide film comprising two polymers:mussel-inspired catechol-conjugated chitosan(Chi-C)with muco-adhesiveness,and alginate(Alg)with anti-adhesion property.The Chi-C and Alg polymers form a stably entangled bilayer film via electrostatic interactions.The Janus film shows a strong tissue adhesive strength of~10 kPa for the Chi-C layer and weak strength of~1 kPa for the Alg layer.Particularly,the Janus film encapsulating an anti-cancer drug exhibits a directional release profile to the tumor site,which is effective for triggering tumor death in in vivo colorectal tumor resection model.Ultimately,such anti-cancer material strategies using bilayered structures are promising for advanced tumor therapy.

关 键 词：ANTIFOULING colon cancer MUCOADHESIVE polysaccharide film 

分 类 号：R318[医药卫生—生物医学工程] R735.3[医药卫生—基础医学]