Regulatory mechanisms and regeneration strategies of the soft-hard tissue interface in the human periodontium  

作　　者：Gao-peng Dang Yu Wei Qian-qian Wan Jun-ting Gu Kai-yan Wang Mei-chen Wan Chen-yu Wang Jing-han Song Zhao Mu Franklin R.Tay Li-na Niu 

机构地区：[1]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology,School of Stomatology,The Fourth Military Medical University,Xi'an,China [2]The Dental College of Georgia,Augusta University,Augusta,USA

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第3期28-50,共23页生物医学工程材料（英文）

基　　金：Shaanxi Key Scientific and Technological Innovation Team of China,Grant/Award Number:2020TD-033;National Key Research and Development Program of China,Grant/Award Numbers:2022YFC2405900,2022YFC2405901;National Natural Science Foundation of China,Grant/Award Numbers:81870805,82325012;National Clinical Research Center for Oral Diseases of China,Grant/Award Number:LCA202004。

摘　　要：The soft-hard tissue interface of the human periodontium is responsible for periodontal homeostasis and is essential for normal oral activities.This softhard tissue interface is formed by the direct insertion of fibrous ligaments into the bone tissue.It differs from the unique four-layer structure of the fibrocartilage interface.This interface is formed by a combination of physical,chemical,and biological factors.The physiological functions of this interface are regulated by different signaling pathways.The unique structure of this soft-hard tissue interface has inspired scientists to construct biomimetic gradient structures.These biomimetic systems include nanofiber scaffolds,cell sheets,and hydrogels.Exploring methods to repair this soft-hard tissue interface can help solve clinically unresolved problems.The present review examines the structure of the soft-hard tissue interface of the periodontium and the factors that influence the development of this interface.Relevant regulatory pathways and biomimetic reconstruction methods are also presented to provide ideas for future research on interfacial tissue engineering.

关 键 词：interface tissue engineering oral health periodontal ligament soft-hard tissue interface tissue repair 

分 类 号：R78[医药卫生—口腔医学]