Enhancing diaphragmatic defect repair and regeneration:How biomaterials leading the way to progress?  

作　　者：Mojtaba Farahani Przemysław Gnatowski Raziyeh Najafloo Tina Navaei Edyta Piłat Justyna Kucińska-Lipka Mohammad Reza Saeb Masoud Mozafari 

机构地区：[1]Institute of Biomedical Engineering,Department of Pharmacology and Physiology,Faculty of Medicine,University of Montreal,Montreal,Canada [2]Research Center,Centre Hospitalier Universitaire Sainte-Justine,Montreal,Canada [3]Department of Polymer Technology,Faculty of Chemistry,Gdańsk University of Technology,Gdańsk,Poland [4]Faculty of Sustainable Design Engineering,University of Prince Edward Island,Charlottetown,Canada [5]Department of Pharmaceutical Chemistry,Medical University of Gdańsk,Gdańsk,Poland [6]Research Unit of Medical Imaging,Physics and Technology,Faculty of Medicine,University of Oulu,Oulu,Finland

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第3期92-107,共16页生物医学工程材料（英文）

基　　金：Politechnika Gdańska,Grant/Award Number:DEC20/1/2022/IDUB/III。

摘　　要：Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations.Diaphragmatic hernias,such as Morgagni,Bochdalek,and Hiatus hernias,can result in congenital lesions that are often undiagnosed until the appearance of symptoms(bleeding,anemia,and acid reflux).Therefore,substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics.Recent research indicates promising mid-term performance for both natural and synthetic materials.However,studies exploring their application in diaphragm regeneration are limited and remain in the early research stages.Additionally,further investigation is required to address the constraints in human tissue supply for clinical implementation.This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration.It emphasizes biomaterials,including biomimetic polymers used in technological solutions.This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissueengineered patches for clinical use.

关 键 词：BIOMATERIALS DIAPHRAGM diaphragmatic defects HERNIA scaffolds 

分 类 号：R318[医药卫生—生物医学工程]