Advanced near-infrared light approaches for neuroimaging and neuromodulation  

作　　者：Hongqiang Yin Wuqiao Jiang Yongyang Liu Dongyang Zhang Feng Wu Yejun Zhang Chunyan Li Guangcun Chen Qiangbin Wang 

机构地区：[1]CAS Key Laboratory of Nano-Bio Interface,Suzhou Key Laboratory of Functional Molecular Imaging Technology,Division of Nanobiomedicine and i-Lab,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou,China [2]School of Nano-Tech and Nano-Bionics,University of Science and Technology of China,Hefei,China [3]College of Materials Sciences and Opto-Electronic Technology,University of Chinese Academy of Sciences,Beijing,China

出　　处：《BMEMat(BioMedical Engineering Materials)》2023年第2期122-152,共31页生物医学工程材料（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22127808,22177128,22204172,21934007,22174158;the National Key Research and Development Program,Grant/Award Number:2021YFF0701804;the Science and Technology Project of Suzhou,Grant/Award Numbers:SZS201904,SJC2021001;the Natural Science Foundation of Jiangsu Province,Grant/Award Numbers:BK20222016,BE2022753,BE2022745;Chinese Academy of Sciences,Grant/Award Numbers:YJKYYQ20200036,121E32KYSB20180021,ZDBS-LY-SLH021。

摘　　要：Almost all physiological processes of animals are controlled by the brain,including language,cognitive,memory,learning,emotion and so forth.Minor brain dysfunction usually leads to brain diseases and disorders.Therefore,it'is greatly meaningful and urgent for scientists to have a better understanding of brain structure and function.Optical approaches can provide powerful tools for imaging and modulating physiological processes of the brain.In particular,optical approaches in the near-infrared(NIR)window(700-1700 nm)exhibit excellent prosperities of deep tissue penetration and low tissue scattering and absorption compared with those of visible windows(400-700 nm),which provides a promising approach for scientists to develop desired methods of neuroimaging and neuromodulation in deep brain tissues.In this review,variable types of NIR light approaches for imaging and modulating neural ions,membrane potential,neurotransmitters,and other critical molecules for brain functions and diseases are summarized.In particular,the latest breakthrough research of brain imaging and brain regulation in the NIR-II window(1000-1700 nm)are highlighted.Finally,we conclude the challenges and prospects of NIR light-based neuroimaging and neuromodulation for both basic brain research and further clinical translation.

关 键 词：NANOPROBES near-infrared light neural ion channels NEUROIMAGING NEUROMODULATION 

分 类 号：TN21[电子电信—物理电子学]