A General Electrochemical Synthesis of Sulfonimidoyl Fluorides,Azides,and Acetates  

作　　者：Yi-Min Jiang Yong-Ying Lin Lingyun Zhu Yi Yu Yuanming Li Yuqi Lin Ke-Yin Ye 

机构地区：[1]Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University),College of Chemistry,Fuzhou University,Fuzhou 350108

出　　处：《CCS Chemistry》2024年第8期2021-2030,共10页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(grant no.22171046);the Hundred-Talent Project of Fujian(grant no.50021113)is gratefully acknowledged.

摘　　要：Sulfonimidoyl fluorides,the aza-bioisostere of sulfonyl fluorides,are emerging as a promising linkage agent in the sulfur(VI)fluoride exchange reaction(SuFEx).However,conventional synthetic approaches typically require the use of either unstable sulfonimidoyl chlorides,toxic and corrosive sulfur fluorides,or expensive electrophilic fluorinating agents.Herein,we report an electrochemistry-enabled oxidative nucleophilic fluorination of readily available and bench-stable sulfinamides using a commercially available and easy-to-handle triethylamine trihydrofluoride.With other nucleophilic agents,this electrochemical approach also serves as a general approach to diverse sulfonimidoyl derivatives,including sulfonimidoyl azides and acetates.

关 键 词：ELECTROCHEMISTRY click chemistry sulfur(VI)fluoride exchange reaction sulfonimidoyl fluoride SULFINAMIDE 

分 类 号：O62[理学—有机化学]