Asymmetric Nucleophilic Additions Promoted by Quaternary Phosphonium Ion-Pair Catalysts  

作　　者：Lingzhu Chen Youlin Deng Tingting Li Deyu Hu Xiaoyu Ren Tianli Wang 

机构地区：[1]State Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Center for R&D of Fine Chemicals,Guizhou University,Guiyang 550025 [2]Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064

出　　处：《CCS Chemistry》2024年第9期2110-2130,共21页中国化学会会刊（英文）

基　　金：Financial support was provided by the National Natural Science Foundation of China(grant nos.22222109,21921002,22101189,21897002,and 31972290);the Beijing National Laboratory for Molecular Sciences(grant no.BNLMS202101);the Natural Science Foundation of Sichuan Province(grant nos.2023NSFSC1921,2022NSFSC1181,and 24NSFSC6590);the Fundamental Research Funds from Sichuan University(grant no.2020SCUNL108);the Fundamental Research Funds for the Central Universities.

摘　　要：Chiral quaternary phosphonium ion-pair catalysis showcases a distinctive catalytic and stereoinductive mode arising from the synergy between ionic and noncovalent interactions.Over recent decades,this methodology has been widely adopted to facilitate enantioselective nucleophilic addition reactions,including conjugate addition,Henry reaction,Mannich reaction,Strecker reaction,and hydrophosphonylation.This strategy has been successfully applied to the synthesis of numerous structurally diverse and multifunctionalized molecules,featuring challenging stereogenic centers.This minireview specifically highlights the accomplishments in asymmetric nucleophilic addition facilitated by chiral quaternary phosphonium catalysts.Its purpose is to cultivate interest among researchers,encouraging more engagement in this field and establishing quaternary phosphonium ion-pair catalysis as a potent and dependable tool for synthetic and pharmaceutical chemists.

关 键 词：quaternary phosphonium salts ion-pair catalysts asymmetric synthesis ORGANOCATALYSIS nucleophilic addition 

分 类 号：O62[理学—有机化学]