Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression  

作　　者：Mengyu Lai Jiaomeng Li Jiaying Yang Qingli Zhang Yujia Gong Yuhang Ma Fang Fang Na Li Yingxiang Zhai Tingting Shen Yongde Peng Jia Liu Yufan Wang 

机构地区：[1]Department of Endocrinology and Metabolism,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [2]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]School of Pharmacy,Henan University,Kaifeng 475004,China [4]School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310058,China

出　　处：《Journal of Molecular Cell Biology》2024年第3期35-45,共11页分子细胞生物学报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(81870610);Shanghai Science and Technology Commission Foundation(21Y11904800 and 23ZR1451500);the Clinical Research Plan of SHDC(SHDC2020CR3065B);the National Key Research and Development Program of China(2021YFC2501600 and 2021YFC2501601).

摘　　要：Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly elucidated.Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression.Therefore,in the present study,we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three trimesters.We found that the variation trends of 38 metabolites were significantly changed during GDM development.Specifically,longitudinal analyses revealed that cysteine(Cys)levels significantly decreased over the course of GDM progression.Further study showed that Cys alleviated GDM in female mice at gestational day 14.5,possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis.Taken together,these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.

关 键 词：gestational diabetes mellitus metabolomics CYSTEINE 

分 类 号：R714.256[医药卫生—妇产科学]