0.05%环孢素滴眼液对糖尿病视网膜病变患者玻璃体切割术后泪膜稳定性和眼表功能的影响  

Effect of 0.05%cyclosporine eye drops on tear film stability and ocular surface function in patients with diabetic retinopathy after vitrectomy

作　　者：高桂芬 王贺 徐为海 李明新 GAO Gui-fen;WANG He;XU Wei-hai;LI Ming-xin(Department of Ophthalmology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000;Binhai County People's Hospital,Yancheng 224500,Jiangsu,China)

机构地区：[1]徐州医科大学附属医院眼科,江苏徐州221000 [2]滨海县人民医院眼科,江苏盐城224500

出　　处：《川北医学院学报》2024年第10期1390-1394,共5页Journal of North Sichuan Medical College

基　　金：徐州医科大学附属医院发展基金项目(XYFY2021012)。

摘　　要：目的:探讨0.05%环孢素滴眼液对糖尿病视网膜病变(DR)玻璃体切割术后患者干眼症状、体征和眼表功能的影响。方法:选取100例行玻璃体切割术的DR患者为研究对象,按照干预方式不同分为实验组(n=50,50眼,右眼)和对照组(n=50,50眼,右眼)。实验组使用0.05%环孢素滴眼液治疗;对照组使用0.3%玻璃酸钠滴眼液治疗。治疗前和治疗后1、4、12周,评估患者眼表疾病指数(OSDI)、非侵入性首次泪膜破裂时间(NIBUTf)、非侵入性平均泪膜破裂时间(NIBUTav)、非侵入式泪河高度(NITMH)、睑板腺缺失度评分、泪膜脂质层厚度评分、眼红分析、眼表染色评分(OSS)和最佳矫正视力(BCVA),并记录治疗期间发生的不良反应。结果:治疗后各时间点,实验组OSDI评分均低于对照组(P<0.05),NITMH和BCVA均高于对照组(P<0.05);治疗后4、12周,实验组NIBUTf、NIBUTav均高于对照组(P<0.05),OSS评分均低于对照组(P<0.05);治疗后12周,实验组泪膜脂质层厚度评分高于对照组(P<0.05);治疗前后各时间点,两组睑板腺缺失度评分和眼红指数差异均无统计学意义(P>0.05);实验组与对照组均未发生严重不良反应。结论:0.05%环孢素滴眼液在DR患者玻璃体切割术后能够有效改善干眼症状,提高泪膜稳定性,改善眼表功能参数,且安全性较高。Objective:To explore the effect of 0.05%cyclosporine eye drops on dry eye symptoms,signs and ocular surface function in patients with diabetic retinopathy(DR)after vitrectomy.Methods:100 patients with DR who underwent vitrectomy were selected.They were divided into Experimental group(n=50,50 eyes,right eye)and control group(n=50,50 eyes,right eye)according to the different ways of intervention.The Experimental group was treated with 0.05%cyclosporine eye drops,while the control group was treated with 0.3%sodium hyaluronate eye drops.Before treatment and 1,4 and 12 weeks after treatment,the ocular surface disease index(OSDI),non-invasive first tear film break-up time(NIBUTf),non-invasive average tear film break-up time(NIBUTav),non-invasive tear meniscus height(NITMH),meibomian gland loss score,tear film lipid layer thickness score,eye red analysis,ocular staining score(OSS)and best corrected visual acuity(BCVA)were evaluated.Adverse reactions during treatment were recorded.Results:At each time point after treatment,the OSDI score of the experimental group was lower than that of the control group(P<.05),and the NITMH and BCVA were higher than thaose of the control group(P<0.05).At 4 and 12 weeks after treatment,NIBUTf and NIBUTav in the experimental group were higher than those in the control group(P<0.05),and OSS score was lower than that in the control group(P<0.05).At 12 weeks after treatment,the tear film lipid layer thickness score of the experimental group was higher than that of the control group(P<0.05).There was no significant difference in meibomian gland loss score and redness index between the two groups at each time point before and after treatment(P>0.05).No serious adverse reactions occurred in the experimental group and the control group.Conclusion:0.05%cyclosporine eye drops can effectively improve the symptoms of dry eye,improve the stability of tear film,improve the functional parameters of ocular surface after vitrectomy in DR patients,and have high safety.

关 键 词：0.05%环孢素滴眼液 糖尿病视网膜病变 玻璃体切割术 泪膜稳定性 

分 类 号：R774[医药卫生—眼科]