锦红片联合西医治疗急性胰腺炎的疗效及对炎症反应和肠黏膜屏障功能的影响  

Efficacy of Jinhong Tablets combined with western medicine in treatment of acute pancreatitis and its influence on inflammatory response and intestinal mucosal barrier function in patients

作　　者：叶圳 顾宏刚[1] 李炯[1] 沈通一[2] 旋玉君 程琳 YE Zhen;GU Hong-gang;LI Jiong;SHEN Tong-yi;XUAN Yu-jun;CHENG Lin(Department of General Surgery I,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Department of General Surgery,Shanghai Tenth People's Hospital,Shanghai 200072;Department of General Surgery,Shanghai Dahua Hospital,Shanghai 200237,China)

机构地区：[1]上海中医药大学附属龙华医院普外一科,上海200032 [2]上海市第十人民医院普外科,上海200072 [3]上海市大华医院普外科,上海200237

出　　处：《川北医学院学报》2024年第10期1395-1398,共4页Journal of North Sichuan Medical College

基　　金：上海中医药大学科技发展项目(23KFL073)。

摘　　要：目的:探讨锦红片联合西医治疗急性胰腺炎(AP)的疗效及对炎症反应和肠黏膜屏障功能的影响。方法:选取298例AP患者为研究对象,依据治疗方案不同分为西医组和锦红片组,每组各149例。西医组患者给予常规西医治疗;锦红片组患者给予锦红片联合西医治疗,疗程均为7 d。比较两组患者临床疗效、中医证候积分、血淀粉酶、尿淀粉酶水平、炎症因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素6(IL-6)]水平及肠黏膜屏障功能[二胺氧化酶(DAO)、内毒素水平]及不良反应发生情况。结果:治疗后,锦红片组患者临床总有效率高于西医组(91.95%vs.73.15%,P<0.05);中医证候积分、血淀粉酶、尿淀粉酶及血清CRP、PCT、IL-6、DAO、内毒素水平低于西医组(P<0.05)。治疗期间两组患者均未发生严重药物不良反应。结论:在西医治疗的基础上加用锦红片可提高AP临床疗效,改善临床症状,减轻炎症反应,保护肠黏膜屏障功能。Objective:To explore the effect of Jinhong Tablets combined with western medicine on acute pancreatitis(AP)and its effect on inflammatory response and intestinal mucosal barrier function.Methods:298 patients with AP were divided into western medicine group(n=149)and Jinhong tablet group(n=149)according to the treatment plan.The western medicine group was treated with conventional western medicine,and the Jinhong Tablets group was treated with Jinhong Tablets combined with western medicine.The course of treatment was 7 days.The clinical efficacy,TCM syndrome score,blood and urine amylase,inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)],intestinal mucosal barrier function[diamine oxidase(DAO),endotoxin],and incidence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of Jinhong Tablets group was higher than that of Western medicine group(91.95%vs.73.15%,P<0.05).The TCM syndrome score,hematuria amylase,serum CRP,PCT and IL-6,DAO and endotoxin levels in the Jinhong Tablets group were lower than those in the western medicine group(P<0.05).During the treatment period,neither group of patients experienced serious adverse reactions.Conclusion:On the basis of western medicine treatment of AP,Jinhong Tablets can improve the clinical efficacy,improve clinical symptoms,reduce inflammatory reaction and protect intestinal mucosal barrier function.

关 键 词：锦红片 急性胰腺炎 炎症反应 肠黏膜屏障功能 

分 类 号：R574.1[医药卫生—消化系统]