TACE联合射频消融对复发性肝癌患者生存期的影响  

Effect of TACE combined with radiofrequency ablation on survival in patients with recurrent liver cancer

作　　者：应立平 王金发 吴宗杨 YING Liping;WANG Jinfa;WU Zongyang(The Affliated People's Hospital of Ningbo University,Zhejiang 315040,China.)

机构地区：[1]宁波大学附属人民医院,宁波315040

出　　处：《浙江创伤外科》2024年第10期1824-1827,共4页Zhejiang Journal of Traumatic Surgery

基　　金：宁波市鄞州区农业与社会发展科技项目(20191YZQ010004)。

摘　　要：目的探究经导管动脉化疗栓塞(TACE)和射频消融(RFA)对复发性肝癌患者生存期的影响。方法本研究选取2018年5月至2021年5月间,本院收治的复发性肝癌患者80例作为研究对象。所有患者均经病理学确诊为肝癌,且至少接受过一次手术治疗后复发。根据治疗方法的不同,将患者分为对照组和观察组两组。对照组35例患者仅予RFA治疗,而观察组45例患者则接受TACE联合RFA治疗。通过对比分析两组患者术后3年内的无瘤生存率、总生存率和并发症发生率。结果比较术后1年内患者的无瘤生存率和总生存率观察组与对照组差异不显著。术后2、3年内患者的无瘤生存率和总生存率观察组显著高于对照组(P<0.05)。多因素logistic多元回归分析结果发现,复发至手术时间短、TACE联合RFA治疗是影响复发性肝癌患者3年内总生存率的重要因素。结论TACE联合RFA治疗对复发性肝癌患者的生存期具有显著的影响,该方法能够提高患者的无瘤生存率和总生存率,值得在临床上进一步推广和应用。Objective To explore the effect of transcatheter arterial chemoembolization(TACE)and radiofrequency ablation(RFA)on the survival in patients with recurrent liver cancer.Methods 80 patients with recurrent liver cancer admitted to our hospital from May 2018 to May 2021 were selected as the research subjects.All patients were pathologically diagnosed with liver cancer and had relapsed after at least one surgical treatment.According to the different treatment methods,the patients were divided into two groups:control group and observation group.35 patients in the control group were treated with RFA alone,while 45 patients in the observation group were treated with TACE combined with RFA.The tumor-free survival rate,overall survival rate and complication rates of the two groups within 3 years after surgery were compared and analyzed.Results There was no significant difference between the observation group and the control group in terms of tumor-free survival and overall survival within 1 year after surgery.The tumor-free survival rate and overall survival rate of patients in the observation group were significantly higher than those in the control group within 2 and 3 years after surgery(P<0.05).The results of multivariate logistic multiple regression analysis showed that the short time from recurrence to surgery and TACE combined with RFA therapy were important factors affecting the overall survival rate of patients with recurrent liver cancer within 3 years.Conclusion TACE combined with RFA therapy has a significant impact on the survival of patients with recurrent liver cancer,and this method can improve the tumor-free survival rate and overall survival rate of patients,which is worthy of further promotion and application in clinical practice.

关 键 词：经导管动脉化疗栓塞(TACE) 射频消融(RFA) 复发性肝癌 生存期 

分 类 号：R735.7[医药卫生—肿瘤]