Glisson鞘外血流阻断对肝癌合并肝硬化手术的疗效  

The impact of Glisson extrinsic blood flow blockage and Pringle complete hepatic blood flow blockade on hepatocellular cancer in patients with cirrhosis is examined in this study

作　　者：邱文龙 潘林锋 孙炳杰 QIU Wenlong;PAN Linfeng;SUN Bingjie(Zhejiang Zhoushan Hospital,Zhejiang 316100,China.)

机构地区：[1]浙江省舟山医院,舟山316100

出　　处：《浙江创伤外科》2024年第10期1827-1830,共4页Zhejiang Journal of Traumatic Surgery

基　　金：浙江省中医药科技计划项目(2022ZB385)。

摘　　要：目的研究Glisson鞘外血流阻断与Pringle全入肝血流阻断对肝癌合并肝硬化手术的疗效的影响。方法纳入2021年9月至2023年8月在本院接受手术治疗的90例肝癌合并肝硬化患者进行前瞻性研究,按照随机数表法进行分组,A组45例给予Glisson鞘外血流阻断,B组45例给予Pringle全入肝血流阻断。比较两组围术期相关指标、肝功能指标、并发症及复发情况。结果A组围术期相关指标均显著优于B组,差异有统计学意义(P<0.05)。两组术后1周时的肝功能各项指标水平相比,A组相对更低,差异有统计学意义(P<0.05)。A组术后并发症发生率为4.44%(2/45),较B组20.00%(9/45)更低,差异有统计学意义(P<0.05)。A组术后复发率为22.22%(10/45),和B组26.67%(12/45)相比,差异无统计学意义(P>0.05)。结论与Pringle全入肝血流阻断相比,在肝癌合并肝硬化手术中采用Glisson鞘外血流阻断可取得较好手术疗效,可有效促进患者肝功能好转,减少并发症,促进术后恢复,优势较为显著,具有较高的使用价值。Objective To compare the effects of Glisson extrinsic blood flow blockade and Pringle complete hepatic blood flow blockade on surgical outcomes in patients with hepatocellular carcinoma(HCC)and cirrhosis.Methods A prospective study was conducted on 90 patients with HCC and cirrhosis who underwent surgery from September 2021 to August 2023.The patients were randomly assigned to Group A(Glisson extrinsic blood flow blockade,n=45)or Group B(Pringle complete hepatic blood flow blockade,n=45).Perioperative outcomes,liver function,complications,and recurrence rates were compared between the two groups.Results Group A demonstrated significantly better perioperative outcomes compared to Group B(P<0.05).At 1 week postoperatively,liver function in Group A was superior to that in Group B(P<0.05).The incidence of complications was lower in Group A(4.44%)than in Group B(20.00%)(P<0.05).Recurrence rates between the two groups were not significantly different(P>0.05).Conclusion Compared to Pringle complete hepatic blood flow blockade,Glisson extrinsic blood flow blockade offers better surgical outcomes,improved liver function recovery,and fewer complications in patients with HCC and cirrhosis,making it a promising approach for clinical use.

关 键 词：肝癌合并肝硬化 手术疗效 Glisson鞘外血流阻断 肝功能 Pringle全入肝血流阻断 

分 类 号：R735.7[医药卫生—肿瘤]