小剂量奥氮平联合舍曲林治疗伴非自杀性自伤行为青少年抑郁患者的疗效评估  

Evaluation of the efficacy of low-dose olanzapine combined with sertraline in the treatment of depressed adolescents with non-suicidal self-injury

作　　者：陈灵肖 张丽媛 戴立磊 戴炜 CHEN Ling-xiao;ZHANG Li-yuan;DAI Li-lei;DAI Wei(Jingmen Dongbao Hospital,Jinmen 448000,China)

机构地区：[1]荆门市人民医院,448000 [2]荆门东宝医院

出　　处：《临床精神医学杂志》2024年第5期341-343,共3页Journal of Clinical Psychiatry

基　　金：湖北省重点研发计划项目(2022BCE032);荆门市一般科技计划项目(2023YFYB002,2021YFYB044)。

摘　　要：目的:探讨小剂量奥氮平联合舍曲林治疗伴非自杀性自伤(non-suicidal self-injury,NSSI)行为青少年抑郁患者的疗效及耐受性。方法:随机选取在我院治疗的青少年抑郁症伴NSSI患者60例,分为30例口服舍曲林对照组和30例在口服舍曲林基础上合用小剂量奥氮平的研究组,治疗前及治疗1、2、4周末采用汉密尔顿抑郁量表17项(Hamilton depression scale-17 items,HAMD-17)和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评价总体疗效,采用渥太华自我伤害调查表(Ottawa self-injury inventory,OSI)评估NSSI行为发生情况。结果:两组患者干预前HAMD-17、HAMA评分比较差异无统计学意义(P>0.05);治疗1,2,4周末研究组HAMD-17、HAMA评分低于对照组,NSSI行为发生率低于对照组,差异均有统计学意义(P均<0.05);治疗4周研究组痊愈率及有效率高于对照组,差异有统计学意义(P<0.05)。结论:小剂量奥氮平联合舍曲林治疗伴NSSI行为青少年抑郁患者疗效显著。Objective:To investigate the efficacy and tolerability of low-dose olanzapine combined with sertraline in the treatment of adolescents with depression associated with non-suicidal self-injury(NSSI).Method:A total of 60 adolescent depression patients with NSSI treated in our hospital were randomly selected and divided into the control group(30 cases oral sertraline)and the study group(30 cases oral sertraline combined with low-dose olanzapine).At baseline and at the end of week1,week2,and week4 after treatment,Hamilton depression scale-17 items(HAMD-17)and Hamilton anxiety scale(HAMA)were used to evaluate the overall efficacy of the two groups,the occurrence of NSSI behavior was assessed by Ottawa self-injury inventory(OSI).Results:There were no significant difference in HAMD-17 and HAMA scores between the two groups before intervention(P>0.05);at the end of week1,week2,and week4 after treatment,HAMD-17 and HAMA scores of the study group were lower than those of the control group,and the incidence of NSSI behavior in the study group was lower than that of the control group,with statistical significance(P<0.05).After 4 weeks of treatment,the recovery rate and effective rate of the study group were higher than those of the control group with statistically significant(P<0.05).Conclusion:Low dose olanzapine combined with sertraline is effective in the treatment of depressive adolescents with NSSI.

关 键 词：非自杀性自伤 奥氮平 舍曲林 

分 类 号：R749.4[医药卫生—神经病学与精神病学]