去甲肾上腺素转运体基因多态性与汉族抑郁症患者自我攻击行为的关系  

Relationship between norepinephrine transporter gene polymorphism and self aggressive behavior in Han patients with depression

作　　者：张文琼 金华 周楠 李亚辰[1] 王立娜[1] ZHANG Wen-qiong;JIN Hua;ZHOU Nan;LI Ya-chen;WANG Li-na(Tianjin Anding Hospital,Tianjin 300000,China)

机构地区：[1]天津市安定医院,300000

出　　处：《临床精神医学杂志》2024年第5期354-358,共5页Journal of Clinical Psychiatry

摘　　要：目的:探讨去甲肾上腺素转运体(norepinephrine transporter,NET)基因的基因多态性与汉族抑郁症患者自我攻击行为的关系。方法:选取2018年1月至2021年5月天津安定医院门诊收治的161例汉族抑郁症患者为研究组,另选取同期健康体检的165名汉族人群作为对照组。比较2组相关基因型与等位基因分布情况。分析NET基因多态性与汉族抑郁症患者自我攻击行为的关系。结果:研究组相关基因型及等位基因分布频率均高于对照组(P均<0.05);伴自我攻击行为组相关基因及等位基因分布频率均高于未伴自我攻击行为组(P均<0.05);性别、精神疾病家族史等因素均是汉族抑郁症患者自我攻击行为的危险因素。结论:G1287A基因型AA、等位基因A及T182C基因型CC、等位基因C分布频率可能是汉族抑郁症患者伴发自我攻击行为的危险因素。Objective:Exploring the relationship between the NET gene polymorphism and self aggressive behavior in Han depression patients.Method:One hundred and sixty one Han depression patients admitted to outpatient clinics of Tianjing Anding hospital from January 2018 to May 2021 were selected as the study group,and another 165 Han population who underwent health examinations during the same period were selected as the control group.Compare the distribution of two related genotypes and alleles.Analyze the relationship between NET gene polymorphism and self aggressive behavior in Han depression patients.Results:The distribution frequency of related genotypes and alleles in the research group was higher than that in the control group(P<0.05);The distribution frequency of related genes and alleles in the group with self aggressive behavior was higher than that in the group without self aggressive behavior(P<0.05);Gender,family history of mental illness,and other factors are all risk factors for self aggressive behavior in Han depression patients.Conclusion:The distribution frequency of G1287A genotype AA,allele A,T182C genotype CC,and allele C may be risk factors for self aggressive behavior in Han depression patients.

关 键 词：去甲肾上腺素转运体 基因多态性 抑郁症 攻击行为 

分 类 号：R749.4[医药卫生—神经病学与精神病学]