精神分裂症患者神经细胞黏附分子、视锥蛋白样蛋白-1表达与认知功能障碍的相关性分析  

Correlation analysis of neural cell adhesion molecules,cone-like protein-1 expression and cognitive dysfunction in schizophrenia

作　　者：孙李晴 江依勇 蔡溢 肖剑英[2] SUN Li-qing;JIANG Yi-yong;CAI Yi;XIAO Jian-ying(Shenzhen Kangning hospital,Shenzhen 518118,China)

机构地区：[1]深圳市康宁医院,518118 [2]湖南省脑科医院老年及躯体疾病精神科

出　　处：《临床精神医学杂志》2024年第5期369-372,共4页Journal of Clinical Psychiatry

摘　　要：目的:分析精神分裂症患者神经细胞黏附分子(nerve cell adhesion molecule,NCAM)、视锥蛋白样蛋白-1(cone-like protein-1,VILIP-1)表达与认知功能障碍的相关性分析。方法:选取进行治疗的精神分裂症患者65例为疾病组,进行健康体检的人员60名为健康组。检测白细胞介素-1β(interleukin-1β,IL-1β)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(IL-6)、NCAM、VILIP-1;采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)对患者精神分裂症严重情况进行评定;蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)对患者自身认知功能情况进行评估。结果:与健康组相比,疾病组NCAM表达水平降低,VILIP-1升高(P均<0.05);NCAM与PANSS评分之间呈负相关性,NCAM与MoCA评分之间呈正相关性(P均<0.05);VILIP-1与PANSS评分之间呈正相关性,VILIP-1与MoCA评分之间呈负相关性(P均<0.05);受试者工作曲线(receiver operation characteristic,ROC)分析显示,与NCAM、VILIP-1单项诊断相比,联合检测对精神分裂症的诊断价值较高(P均<0.05)。结论:精神分裂症患者机体内NCAM和VILIP-1表达水平的异常升高或降低是精神分裂症的风险预测因子,可能与病情的诊断、发展及认知功能等具有紧密关联。Objective:To analyze of the correlation of nerve cell adhesion molecules(NCAM),cone-like protein-1(VILIP-1)expression and cognitive dysfunction in schizophrenia.Method:Sixty-five patients treated for schizophrenia in our hospital were selected as the disease group,and 60 patients treated for health examination in our hospital were selected as the health group.Their interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),NCAM and VILIP-1 were detected;schizophrenia severity and cognitive function were evaluated by positive and negative syndrome scale(PANSS)and Montreal cognitive assessment(MoCA)score.Results:Compared to the healthy group,NCAM expression level was lower in the disease group,expression level of VILIP-1 was higher(all P<0.05);There was a negative correlation between NCAM and PANSS scores,and a positive correlation between NCAM and MoCA score(all P<0.05);there was a positive correlation between VILIP-1 and PANSS scores,and a negative correlation between VILIP-1 and MoCA score(all P<0.05);the receiver operation characteristic(ROC)curve analysis revealed that,compared with the single diagnosis of NCAM and VILIP-1,the combined test had a higher value in the diagnosis of schizophrenia(all P<0.05).Conclusion:The abnormal increased or decreased expression in NCAM and VILIP-1 expression level is a risk predictor of schizophrenia,which may be closely related to the diagnosis,development and cognitive function of the disease.

关 键 词：精神分裂症 神经细胞黏附分子 视锥蛋白样蛋白-1 认知功能障碍 

分 类 号：R749.3[医药卫生—神经病学与精神病学]