多组织包埋在人表皮生长因子受体2免疫组织化学阳性对照制作中的应用  

Application of multi-tissue embedding in the preparation of human epidermal growth factor receptor-2 immunohistochemical positive control

作　　者：陈沛杰 杨敏 陈耿标[1] Chen Peijie;Yang Min;Chen Gengbiao(Department of Pathology,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院病理科,广州510120

出　　处：《实用医技杂志》2024年第8期570-571,共2页Journal of Practical Medical Techniques

摘　　要：目的探讨多组织包埋在人表皮生长因子受体2(HER2)免疫组织化学阳性对照制作中的应用。方法收集2022年8月至2023年8月满足中山大学孙逸仙纪念医院病理科临床诊断后剩余的乳腺癌组织,通过免疫组织化学定位,选取HER2均一表达0、+、++、+++的组织,进行多组织包埋,制作成阳性对照蜡块。结果每张组织化学片中对照组织中均能HER2表达0、+、++、+++。结论多组织包埋可以很好地应用在HER2免疫组织化学阳性对照制作中。Objective To explore the application of multi-tissue embedding in the production of HER2 immunohistochemistry positive controls.Methods The remaining breast cancer tissues that meet the clinical diagnosis of the Pathology Department of Sun Yat-sen Memorial Hospital of Sun Yat-sen University were collected.The tissues that defined as HER2 immunohistochemistry(IHC)scores of 0 or+or++or+++were selected for multi tissue embedding and made into positive control wax blocks.Results HER2 IHC scores of 0 or+or++or+++were observed in the control tissues of each histological slice.Conclusion Multi-tissue embedding can be well applied in the production of human epidermal growth factor receptor-2 immunohistochemistry positive controls.

关 键 词：免疫组织化学 表皮生长因子受体2 阳性对照 制作 多组织包埋 

分 类 号：R737.9[医药卫生—肿瘤]