Coccinia grandis:Phytochemistry,pharmacology and health benefits  

作　　者：MdSabbir Hossain Ishrat Jahan Mumtasin Islam Jannatun Nayeem Tahseen Sharika Anzum Nusyba Aktar Afrin Farjana Karim Mim Md.Kamrul Hasan 

机构地区：[1]Department of Biochemistry and Molecular Biology,Tejgaon College,National University,Gazipur 1700,Bangladesh [2]Department of Public Health,North South University,Dhaka 1229,Bangladesh

出　　处：《Clinical Traditional Medicine and Pharmacology》2024年第3期125-143,共19页临床传统医学和药理学（英文）

摘　　要：Background:Coccinia grandis(L.)Voigt,commonly known as Ivy gourd,is a plant of the Cucurbitaceae family that has been used in traditional medicinal systems for centuries.Its most common traditional use is managing diabetes mellitus which has been scientifically proven along with other pharmacological activities.Objective:This review aims to thoroughly explore the scientific evidence of various pharmacological activities of C.grandis and its therapeutic applications.Method:A thorough search of the literature was carried out to identify relevant research on C.grandis.With the combination of the plants’scientific names,different keywords,such as“Coccinia grandis”“Coccinia indica”“tra-ditional medicine”“ethnobotany”“ethnomedicine”“phytochemistry”“bioactive compounds”“pharmacology”“health benefit”“side effect”“toxicity”and“clinical trial”,have been used for search using Boolean operators.Retrieved articles were strictly screened to maintain inclusion criteria.One hundred and sixty-nine papers were eventually chosen for this review after a thorough examination of the retrieved articles that matched the inclusion and exclusion criteria.Results:C.grandis was found to have a number of compounds that are biologically active and exhibit anti-diabetic,anti-dyslipidemic,anti-obesity,anti-oxidant,anti-inflammation,anti-cancer,analgesic,anti-oxidant,antinocicep-tive,antipyretic,anthelmintic,analgesic,spasmolytic,wound-healing,anti-ulcerogenic,anti-convulsant,hepato-protective and immunomodulatory activities without obvious side effects.Nanoparticles produced from the plant and different extracts of the plant show excellent anti-microbial activity.Conclusion:The scientific evidence encourages exploring more in-depth experimental studies regarding the phar-macological activities to develop C.grandis as a novel therapeutic agent.

关 键 词：C.grandis Ivy gourd CUCURBITACEAE Pharmacological activities ANTI-DIABETIC NANOPARTICLES 

分 类 号：R285[医药卫生—中药学]