Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine  

作　　者：Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal Saurabh Aggarwal Subhash Chandra Havagiray R.Chitme Cassio Rocha Medeiros Micheline de Azevedo Lima Lucia Raquel de Lima Henrique Douglas Melo Coutinho Bhavna Kumar 

机构地区：[1]Department of Pharmacy Practice,School of Pharmaceutical Sciences,SGRR University,Patel Nagar,Dehradun 248001,Uttarakhand,India [2]Department of Medicine,Shri MahantIndiresh Hospital,SGRR University,Patel Nagar,Dehradun 248001,Uttarakhand,India [3]Department of Pharmaceutical Chemistry,School of Pharmaceutical Sciences,SGRR University,Patel Nagar,Dehradun 248001,Uttarakhand,India [4]Department of Pharmacology and Toxicology,Amity Institute of Pharmacy,Amity University,Sector-125,Noida 201313 UP,Gwalior,India [5]CECAPE College,Av.Padre Cícero,3917-São José,Juazeiro do Norte 63024-015,CE,Brazil [6]Department of Molecular Biology,Federal University of Paraiba-UFPB,Joao Pessoa 58051-900,Paraiba,Brazil [7]Department of Biological Chemistry,Regional University of Cariri-URCA,Crato 63105-000,CE,Brazil [8]Department of Pharmaceutics,DIT University,Dehradun 248009,Uttarakhand,India

出　　处：《Clinical Traditional Medicine and Pharmacology》2024年第4期19-26,共8页临床传统医学和药理学（英文）

摘　　要：Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia.Metformin,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic control.Recent studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of life.Medicinal plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin tablet.Objective:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone levels.Methods:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic treatment.This study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic participants.Based on these findings,potential traditional medicines methods for reducing testosterone levels were summarized.Results:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic patients.Several plants were examinedand,and clinical studies were conducted on them.It was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for patients.Conclusion:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dysfunction.While metformin is used to treat T2D

关 键 词：Type 2 diabetes mellitus TESTOSTERONE METFORMIN Erectile dysfunction HYPERGLYCAEMIA 

分 类 号：R587.1[医药卫生—内分泌]