Toxicity and phyto-bioactive constituent of Ficus aurea L. leaf extract: A trado-medicinal herb used in southeastern Nigeria  

作　　者：Sonachi Nnedimma Okeke Chinyere Godwin Chinyere Okezie Emmanuel 

机构地区：[1]Department of Biochemistry,Abia State University,Uturu,PMB 2000,Uturu Abia State,Nigeria [2]Department of Animal Sciences,College of Food,Agricultural and Environmental Sciences,the Ohio State University,Wooster,OH 44691,US

出　　处：《Clinical Traditional Medicine and Pharmacology》2024年第4期54-64,共11页临床传统医学和药理学（英文）

摘　　要：Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal Pharmacopeia.Leaves of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health abnormalities.Objective:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of F.aurea L.(herein afterwards referred to as ELEFA)in albino rats of both sexes.Methods:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of F.aurea.In the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was administered.For the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew copulation.Male groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled water.Standard analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney histopathology.Results:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological properties.These bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic acid.In the acute toxicity,no death was recorded within 24 h following oral administration of ELEFA.Remarkably,haematological and renal biomarkers remained unaltered post-ELEFA administration.However,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative stress.Conclusion:The study emphasized caution regarding higher ELEFA doses,highlighting poten

关 键 词：ANTIOXIDANT Ficus aurea PHYTOCHEMICAL TOXICITY Trado-medicine 

分 类 号：R284[医药卫生—中药学]