Immune cell pair ratio captured by imaging mass cytometry has superior predictive value for prognosis of non-small cell lung cancer than cell fraction and density  

作　　者：Jian-Rong Li Chao Cheng 

机构地区：[1]Institute for Clinical and Translational Research,Baylor College of Medicine,Houston,Texas,USA [2]Section of Epidemiology and Population Sciences,Department of Medicine,Baylor College of Medicine,Houston,Texas,USA [3]Dan L Duncan Comprehensive Cancer Center,Baylor College of Medicine,Houston,Texas,USA

出　　处：《Cancer Communications》2024年第5期589-592,共4页癌症通讯（英文）

基　　金：supported by the Cancer Prevention Research Institute of Texas(CPRIT)(RR180061 to CC);the National Cancer Institute of the National Institute of Health(1R01CA269764 to CC).CC is a CPRIT Scholar in Cancer Research.

摘　　要：Infiltrating immune cells in the tumor microenvironment(TME)play critical roles in the initiation,progression,and metastasis of cancer[1].Previous studies have reported that the infiltration levels of various immune cell types are significantly associated with patient prognosis in different cancers[2,3].Specifically,in non-small cell lung cancer(NSCLC)the prognostic associations of major immune cell types have been investigated[4–6],however,some of the reported associations are inconsistent and remain debated[7].Limited by technical issues,most studies focused on a few immune cell lineages or relied on inferred immune cell levels from computational deconvolution.To investigate the prognostic effects of all major immune cell types unbiasedly,more systematic high-quality immune cell profiling data with matched patient survival information are needed.

关 键 词：PROGNOSIS cancer LUNG 

分 类 号：R734.2[医药卫生—肿瘤]