Single-cell and bulk transcriptomics identifies a tumor-specific CD36^(+)cancer-associated fibroblast subpopulation in colorectal cancer  

作　　者：Jin Wang Ming-Jia Xi Qing Lu Bi-Han Xia Yu-Zhi Liu Jin-Lin Yang 

机构地区：[1]Department of Gastroenterology and Hepatology,West China Hospital,Sichuan University,Chengdu,Sichuan,P.R.China [2]Sichuan University-University of Oxford Huaxi Joint Center for Gastrointestinal Cancer,Frontiers Science Center for Disease-Related Molecular Network,West China Hospital,Sichuan University,Chengdu,Sichuan,P.R.China

出　　处：《Cancer Communications》2024年第4期495-498,共4页癌症通讯（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.82173253);the Sichuan Province Science and Technology Support Program(No.2022YFH0003 and No.2023NSFSC1900);the Postdoctoral Research Foundation of China(No.2022M712260).

摘　　要：Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their various roles in remodeling the extracellular matrix,suppressing the immune response and reprogramming tumor metabolism[1].However,many challenges exist in revealing the func-tional phenotypes and mechanisms of CAFs in different cancers due to limited understanding of CAF hetero-geneity[2].

关 键 词：CD36 metabolism colorectal 

分 类 号：R730[医药卫生—肿瘤]