“Find Me”and“Eat Me”signals:tools to drive phagocytic processes for modulating antitumor immunity  

作　　者：Lingjun Xiao Louqian Zhang Ciliang Guo Qilei Xin Xiaosong Gu Chunping Jiang Junhua Wu 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,National Institute of Healthcare Data Science at Nanjing University,Jiangsu Key Laboratory of Molecular Medicine,Medical School,Nanjing University,Nanjing,Jiangsu,P.R.China [2]Jinan Microecological Biomedicine Shandong Laboratory,Jinan,Shandong,P.R.China

出　　处：《Cancer Communications》2024年第7期791-832,共42页癌症通讯（英文）

基　　金：Shandong Provincial Laboratory Project,Grant/Award Number:SYS202202;National Natural Science Foundation of China,Grant/Award Numbers:81972888,82272819;Research Project of Jinan Microecological Biomedicine Shandong Laboratory,Grant/Award Numbers:JNL-202219B,JNL-202204A,JNL-2023017D;Jiangsu Provincial Key Research and Development Program,Grant/Award Number:BE2022840;Nanjing University of Chinese Medicine,Grant/Award Number:2020YLXK007。

摘　　要：Phagocytosis,a vital defense mechanism,involves the recognition and elimination of foreign substances by cells.Phagocytes,such as neutrophils and macrophages,rapidly respond to invaders;macrophages are especially important in later stages of the immune response.They detect“find me”signals to locate apoptotic cells and migrate toward them.Apoptotic cells then send“eat me”signals that are recognized by phagocytes via specific receptors.“Find me”and“eat me”signals can be strategically harnessed to modulate antitumor immunity in support of cancer therapy.These signals,such as calreticulin and phosphatidylserine,mediate potent pro-phagocytic effects,thereby promoting the engulfment of dying cells or their remnants by macrophages,neutrophils,and dendritic cells and inducing tumor cell death.This review summarizes the phagocytic“find me”and“eat me”signals,including their concepts,signaling mechanisms,involved ligands,and functions.Furthermore,we delineate the relationships between“find me”and“eat me”signaling molecules and tumors,especially the roles of these molecules in tumor initiation,progression,diagnosis,and patient prognosis.The interplay of these signals with tumor biology is elucidated,and specific approaches to modulate“find me”and“eat me”signals and enhance antitumor immunity are explored.Additionally,novel therapeutic strategies that combine“find me”and“eat me”signals to better bridge innate and adaptive immunity in the treatment of cancer patients are discussed.

关 键 词：cancer immunotherapy CARL CX3CL1 “Eat me”signal “Find me”signal Fc LPC PHAGOCYTOSIS PtSer SLAMF7 

分 类 号：R730.3[医药卫生—肿瘤]