慢性乙型肝炎中医证型及证素分布规律研究  

A study of the distribution of chinese medical pattern and pattern element in chronic hepatitis B

作　　者：李思泽 李小科[1,2] 杜宏波[1,2] 郑世豪[1,2] 邹翔云 杨俞铖 叶永安 LI Si-ze;LI Xiao-ke;DU Hong-bo;YE Yong-an(Department of Spleen and Gastroenterology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,100007,China)

机构地区：[1]北京中医药大学东直门医院脾胃病科,北京100700 [2]北京中医药大学中医肝病研究院

出　　处：《中西医结合肝病杂志》2024年第10期875-878,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家科技重大专项“十三五”课题(No.2018ZX10725505);中央高水平中医医院临床科研业务费项目(No.DZMG-XZYY-23003);北京中医药大学东直门医院2023科技创新专项(No.DZMKJCX-2023-014)。

摘　　要：目的:回顾既往文献,研究慢性乙型肝炎(CHB)的中医证型分布情况,揭示其证型分布规律。方法:检索2007年1月1日至2023年12月31日中国期刊全文数据库、中文科技期刊数据库、万方数据库出版平台、中国中医药数据库及PubMed、EMBASE、Cochrane library数据库,纳入CHB的临床研究文献,对纳入的568篇文献的中医证型、证素进行分析。结果:排名前5的中医证型为肝郁脾虚证、湿热内阻证、肝肾阴虚证、瘀血阻络证、脾肾阳虚证,占总比例的70.56%;排名前5的病位证素为肝、脾、胆、肾、胃,占总比例的99.55%;排名前5的病性证素为湿、热、气虚、血瘀、气滞,占总比例的72.39%。结论:CHB的核心病机为“郁、虚、湿、毒、瘀”,随着CHB中医临床研究的不断推进,CHB中医证型分类标准日趋统一。Objective:Through literature review,the distribution of traditional Chinese medicine(TCM) syndrome types of chronic hepatitis B(CHB) was statistically analyzed and the distribution rules of TCM syndrome types were revealed.Methods:Retrieve clinical research literature on CHB from databases including the Chinese Journal Full-text Database,the Chinese Science and Technology Journals Database,the Wanfang Database publishing platform,the Traditional Chinese Medicine Database of China,PubMed,EMBASE,and the Cochrane Library,spanning from January 1,2007,to December 31,2023.Analyze the Traditional Chinese Medicine syndrome types and syndrome elements in the 568 included studies.Results:The top 5 TCM syndromes were liver depression and spleen deficiency,damp-heat internal obstruction,liver and kidney yin deficiency,blood stasis,and spleen and kidney yang deficiency.These syndromes accounted for 70.56% of the total.Additionally,the top 5 pathogenic syndromes were liver,spleen,gallbladder,kidney,and stomach,which accounted for 99.55% of the total.Lastly,the top 5 pathogenic syndromes were dampness,heat,qi deficiency,blood stasis,and qi stagnation,which accounted for 72.39% of the total.Conclusion:The main cause of chronic hepatitis B is a combination of "depression,deficiency,dampness,toxicity,and stasis".As clinical research on chronic hepatitis B in Chinese medicine advances,there is a growing consensus on the classification criterion for this condition.

关 键 词：慢性乙型肝炎 中医证型 中医证素 分布规律 

分 类 号：R575.1[医药卫生—消化系统] R256.4[医药卫生—内科学]